Recent discoveries concerning the tumor - mesenchymal stem cell interactions

Autor: Paula Y. Lam, Gwendal Lazennec
Přispěvatelé: Sys2Diag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (Sys2Diag), Centre National de la Recherche Scientifique (CNRS)-Alcediag, National University of Singapore (NUS)
Rok vydání: 2016
Předmět:
0301 basic medicine
Cancer Research
Chemokine
Angiogenesis
Neovascularization
Physiologic
[SDV.CAN]Life Sciences [q-bio]/Cancer
Apoptosis
Cell Communication
Bioinformatics
Metastasis
03 medical and health sciences
Cancer-Associated Fibroblasts
MESH: Cell Proliferation
MESH: Tumor Microenvironment
Neoplasms
MESH: Cell Communication
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
Tumor Microenvironment
Genetics
medicine
Animals
Humans
MESH: Animals
MESH: Neoplasms
Cell Proliferation
Tumor microenvironment
MESH: Humans
biology
MESH: Apoptosis
Mesenchymal stem cell
Mesenchymal Stem Cells
medicine.disease
3. Good health
MESH: Cancer-Associated Fibroblasts
MESH: Mesenchymal Stem Cells
030104 developmental biology
Oncology
Cancer management
Cancer cell
Cancer research
biology.protein
Cytokines
Chemokines
MESH: Neovascularization
Physiologic
Zdroj: Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, Elsevier, 2016, 1866 (2), pp.290-299. ⟨10.1016/j.bbcan.2016.10.004⟩
ISSN: 0304-419X
Popis: International audience; Tumor microenvironment plays a crucial role in coordination with cancer cells in the establishment, growth and dissemination of the tumor. Among cells of the microenvironment, mesenchymal stem cells (MSCs) and their ability to evolve into cancer associated fibroblasts (CAFs) have recently generated a major interest in the field. Numerous studies have described the potential pro- or anti-tumorigenic action of MSCs. The goal of this review is to synthesize recent and emerging discoveries concerning the mechanisms by which MSCs can be attracted to tumor sites, how they can generate CAFs and by which way MSCs are able to modulate the growth, response to treatments, angiogenesis, invasion and metastasis of tumors. The understanding of the role of MSCs in tumor development has potential and clinical applications in terms of cancer management.
Databáze: OpenAIRE
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