A homogeneity study using NIR spectroscopy: tracking magnesium stearate in Bohle bin-blender

Autor:	Scott D. Reynolds, Fernando J. Muzzio, Andrew Lange, Joep Timmermans, Nhat-Hang Duong, Paulo E. Arratia
Rok vydání:	2003
Předmět:	Pharmacology Spectroscopy Near-Infrared Chemistry Homogeneity (statistics) Organic Chemistry Near-infrared spectroscopy Analytical chemistry Pharmaceutical Science Model system Lactose Homogenization (chemistry) Bin Excipients chemistry.chemical_compound Drug Discovery Technology Pharmaceutical Magnesium stearate Powders Spectroscopy Cellulose Stearic Acids
Zdroj:	Drug development and industrial pharmacy. 29(6)
ISSN:	0363-9045
Popis:	A method was developed for studying mixing of cohesive pharmaceutical mixtures. A combination of accurate sampling and NIR spectroscopic analysis was developed as a suitable method to determine homogenization of magnesium stearate as a function of blending variables. A typical pharmaceutical blend containing a ratio 35:64:1 lactose, avicel, and magnesium stearate was used as a model system. The method accounted for variability of the concentration of magnesium stearate as well as variability of the excipients. Levels of magnesium stearate as low as 0.05% could be resolved by the method, and showed a predicting confidence interval above 98%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87ba4e3dcb6159034ff67a54012ca69 https://pubmed.ncbi.nlm.nih.gov/12889786 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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