Cognitive reserve is a determinant of social and occupational attainment in patients with pediatric and adult onset multiple sclerosis
| Autor: | Giuseppe Fenu, Clara Grazia Chisari, Elio Prestipino, A. Ghezzi, Marta Simone, Monica Falautano, Eleonora Minacapelli, Mg Marrosu, Eleonora Cocco, Angelo Bellinvia, Lorenzo Razzolini, Maria Pia Amato, Lucia Margari, Niccolai M, Luisa Pastò, Mattia Fonderico, Lorena Pippolo, Laura Tudisco, Emilio Portaccio, Benedetta Goretti, Francesco Patti, Roberto Fratangelo, Lucia Moiola, Rosa Gemma Viterbo |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Employment Male Multiple Sclerosis Socio-professional outcomes Intelligence National Adult Reading Test 03 medical and health sciences 0302 clinical medicine Cognitive Reserve Adult onset multiple sclerosis Cognitive performances Cognitive reserve Pediatric onset multiple sclerosis Rating scale medicine Humans Cognitive Dysfunction 030212 general & internal medicine Age of Onset Expanded Disability Status Scale medicine.diagnostic_test Intelligence quotient business.industry Age Factors General Medicine Neuropsychological test Middle Aged Neurology Socioeconomic Factors Montgomery–Åsberg Depression Rating Scale Educational Status Female Neurology (clinical) business 030217 neurology & neurosurgery Stroop effect Clinical psychology |
| Zdroj: | Multiple sclerosis and related disorders. 42 |
| ISSN: | 2211-0356 |
| Popis: | There is limited information on socio-professional attainment in pediatric-onset multiple sclerosis (POMS) compared with adult-onset MS (AOMS).To assess socio-professional outcomes in POMS and AOMS and variables influencing these outcomes.One-hundred-fifteen AOMS and 111 POMS patients underwent neuropsychological testing (Brief Repeatable Battery, Stroop test), assessment of cognitive reserve (CR) (education, National Adult reading Test -NART, Barratt Simplified Measure of Social Status), fatigue (Fatigue Severity Scale), depression (Montgomery-Åsberg Depression Rating Scale), socio-professional performance (Work and Social Adjustment Scale -WSAS). Prognostic factors were assessed using logistic and linear multivariable regression analyses.34.5% of patients showed CI without significant differences between AOMS and POMS. Cognitively impaired patients were older (p=0.024), had higher EDSS scores (p=0.041) and lower IQ (p0.001) compared with cognitively preserved patients. Better WSAS scores were associated with younger age (p=0.007), lower EDSS (p0.001) and higher educational levels (p=0.001). Fourteen POMS (13%) and six AOMS (5%) achieved a lower educational level compared with their parents (p=0.06). POMS exhibiting a lower than expected educational level, had a lower median IQ compared with the remaining subjects (101 vs 106.5; p=0.03). Unemployment rate was predicted by higher disability (p=0.044) and lower educational levels (p0.001). Occupational complexity was positively correlated to educational level (0.001) and NART scores (0.040).This study underscores the complex relationships between cognition and educational, socioeconomic and professional attainment in MS and supports a protective role of CR in both POMS and AOMS. |
| Databáze: | OpenAIRE |
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