Relationship of methylglyoxal-adduct biogenesis to LDL and triglyceride levels in diabetics
| Autor: | Nikša Turk, Zdenka Turk, Maja Čavlović-Naglić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Glycation End Products Advanced medicine.medical_specialty Hyperlipidemias diabetes advanced glycation process alpha-dicarbonyl intermediates methylglyoxal-adducts General Biochemistry Genetics and Molecular Biology Excretion chemistry.chemical_compound Glycation Internal medicine Diabetes mellitus Hyperlipidemia Diabetes Mellitus medicine Humans Lipolysis General Pharmacology Toxicology and Pharmaceutics Triglycerides Aged Glycemic Aged 80 and over Triglyceride Methylglyoxal Cholesterol LDL General Medicine Middle Aged Pyruvaldehyde medicine.disease Diabetes Mellitus Type 1 Endocrinology Diabetes Mellitus Type 2 chemistry Biochemistry |
| Popis: | Protein glycation leading to advanced glycation- endproducts (AGE) is enhanced in diabetes by increased blood glucose and collateral endogenous production of reactive alpha- dicarbonyls. Among AGE precursors, methylglyoxal (MG) is considered as one of the key intermediates. We hypothesized it to be a common product of both carbonyl and oxidative stress, and investigated its biogenesis in relation to glycemic and lipid status in diabetic patients. Serum and urine MG-adducts were measured by competitive immunofluorometric assay in 83 diabetic and 20 healthy subjects. Key findings A significant association of MG-adducts serum level with LDL (r=0.31 ; p=0.003) was observed. A correlation between LDL-c, HDL-C and PPG as independent variables and serum MG-adducts as a dependent variable was found (p3.0mmol/l discriminated patients with higher serum MG-adducts (p=0.0052), although there was no between-subgroup difference in glycemic control. Patients on statin therapy had a lower MG-adduct level. The positive relationship between LDL-c and MG-adducts (r=0.38 ; p=0.042) was noted in patients free of statin treatment, whereas an inverse tendency was found in the statin-treated subgroup. Significant relationship between LDL and MG-adduct production, as well as tight correlation between triglycerides and urinary MG-adduct excretion suggest that the lipoxidation and glyceraldehyde- 3-phosphate route, along with the glycolytic pathway, might be an important source of MG generation. The glycotoxin methylglyoxal seems to be a common factor linking hyperglycemia and intensive lipolysis, two dominant metabolic changes in diabetes. |
| Databáze: | OpenAIRE |
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