A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection
| Autor: | Sean R. McMaster, Yu Shyr, Eric Sebzda, Pavlo Gilchuk, Sebastian Joyce, Jacob E. Kohlmeier, Kelli L. Boyd, Timothy M. Hill, Whitney Rabacal, Douglas R. Green, Clifford S. Guy, Pengcheng Lu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Receptors CXCR3 Population Gene Expression Mice Transgenic Vaccinia virus CD8-Positive T-Lymphocytes Biology CXCR3 Article General Biochemistry Genetics and Molecular Biology Immunophenotyping Mice 03 medical and health sciences 0302 clinical medicine Immune system Antigen Immunity Vaccinia medicine Animals Cytotoxic T cell Amino Acid Sequence education Antigens Viral Immunity Mucosal Lung Respiratory Tract Infections lcsh:QH301-705.5 Administration Intranasal education.field_of_study Body Weight Vaccination Viral Vaccines Viral Load 3. Good health 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Immunology Immunologic Memory CD8 030215 immunology |
| Zdroj: | Cell Reports, Vol 16, Iss 7, Pp 1800-1809 (2016) |
| ISSN: | 2211-1247 |
| Popis: | Summary The nature and anatomic location of the protective memory CD8 + T cell subset induced by intranasal vaccination remain poorly understood. We developed a vaccination model to assess the anatomic location of protective memory CD8 + T cells and their role in lower airway infections. Memory CD8 + T cells elicited by local intranasal, but not systemic, vaccination with an engineered non-replicative CD8 + T cell-targeted antigen confer enhanced protection to a lethal respiratory viral challenge. This protection depends on a distinct CXCR3 LO resident memory CD8 + T (Trm) cell population that preferentially localizes to the pulmonary interstitium. Because they are positioned close to the mucosa, where infection occurs, interstitial Trm cells act before inflammation can recruit circulating memory CD8 + T cells into the lung tissue. This results in a local protective immune response as early as 1 day post-infection. Hence, vaccine strategies that induce lung interstitial Trm cells may confer better protection against respiratory pathogens. |
| Databáze: | OpenAIRE |
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