Hydrogen sulfide increases after a single hemodialysis session
| Autor: | Diana Lanza, Diego Ingrosso, Immacolata Sepe, Alessandra F. Perna |
|---|---|
| Přispěvatelé: | Perna, Alessandra, Sepe, I, Lanza, D, Ingrosso, Diego |
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Homocysteine Hydrogen sulfide medicine.medical_treatment Nitric oxide Pathogenesis chemistry.chemical_compound In vivo Renal Dialysis Internal medicine medicine Homeostasis Humans Hydrogen Sulfide Dialysis biology Cystathionine gamma-Lyase equipment and supplies Cystathionine beta synthase Up-Regulation Endocrinology chemistry Biochemistry Nephrology biology.protein Hemodialysis Biomarkers |
| Zdroj: | Kidney International. (10):1108-1109 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.2011.285 |
| Popis: | To the Editor: Hydrogen sulfide, H2S, the third endogenous gas with cardiovascular properties after nitric oxide and carbon monoxide, is a newly recognized vasorelaxant, and H2S deficiency is involved in the pathogenesis of hypertension and atherosclerosis.1 We demonstrated that in hemodialysis patients, H2S levels are decreased through transcriptional deregulation of genes encoding H2S-producing enzymes.2 In fact, gene expression of cystathionine γ-lyase (CSE), an enzyme implicated in H2S formation, is downregulated in these patients.2 We measured H2S levels before and after a single standard 4-h hemodialysis session in 131 patients, in two dialysis sessions separated by 1 month. Measurement was performed by a slight modification of our previously published method.2 Basically, a 20-min incubation period was added before deproteinization. Homocysteine is a main direct H2S precursor in vivo, which functions through the catalytic activity of either cystathionine β-synthase or CSE (see Perna et al.3 for a review). Plasma total homocysteine was also measured by using high-performance liquid chromatography separation and fluorescence detection.4 |
| Databáze: | OpenAIRE |
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