Distribution of SCEs in lymphocytes in persons with normal, slightly increased, and heavily increased SCEs
| Autor: | Erik Niebuhr, Anne Marie Plesner, Hans Christian Wulf, B. Husum |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Health Toxicology and Mutagenesis Antineoplastic Agents Poisson distribution symbols.namesake Reference Values Internal medicine Genetics medicine Gamma distribution Distribution (pharmacology) Humans Crossing Over Genetic Lymphocytes Molecular Biology Melphalan Aged Chemistry Smoking Middle Aged Endocrinology symbols Female Multiple Myeloma Sister Chromatid Exchange |
| Zdroj: | Mutation research. 125(2) |
| ISSN: | 0027-5107 |
| Popis: | The distribution of SCEs in lymphocytes was examined for 165 healthy persons (58 non-smokers and 107 smokers with cigarette consumption ranging from 1 to greater than 20 per day), and for 1 patient treated with melphalan, a cytostatic drug. The data from the healthy persons did not follow a Poisson distribution. A mixed Poisson that allowed different lambda values for the 30 cells scored from each person and postulated a gamma distribution for the lambda s within the 30 cells fitted all the data examined including those from the melphalan-treated patient. In the latter case the 7 samples taken at various times after the treatment could all be represented satisfactorily with a common parameter, c, in the gamma distribution for the lambda s, even though the mean SCEs/cell varied from 9.8 to 36.8. Because the c parameter determines the spread of lambda values within the 30 cells, this suggested that the effect of the cytostatic drug was to increase all the lambda s by a constant amount. The sum of the SCEs taken over all 30 cells in a sample is a convenient summary statistic, and the transformation y = square root s + square root s + 1 behaves as a normal variate with a constant variance within a group. |
| Databáze: | OpenAIRE |
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