Effects of carbon dioxide exposure on early brain development in rats
| Autor: | M. Evren, Nazan Uysal, Ali Riza Sisman, Basak Baykara, Mehmet Ates, Ayfer Dayi, Ilkay Aksu, Muge Kiray, Ulas M. Camsari |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Histology Prefrontal Cortex Hippocampus medicine.disease_cause Amygdala Superoxide dismutase chemistry.chemical_compound Corticosterone Internal medicine medicine Animals Insulin-Like Growth Factor I Rats Wistar Maze Learning Prefrontal cortex chemistry.chemical_classification Air Pollutants biology business.industry Glutathione peroxidase Brain General Medicine Carbon Dioxide Enzyme assay Rats Medical Laboratory Technology medicine.anatomical_structure Endocrinology nervous system chemistry Anesthesia biology.protein Female business Blood Chemical Analysis Oxidative stress |
| Zdroj: | Biotechnic & Histochemistry. 89:371-383 |
| ISSN: | 1473-7760 1052-0295 |
| DOI: | 10.3109/10520295.2013.872298 |
| Popis: | The developing brain is vulnerable to environmental factors. We investigated the effects of air that contained 0.05, 0.1 and 0.3% CO2 on the hippocampus, prefrontal cortex (PFC) and amygdala. We focused on the circuitry involved in the neurobiology of anxiety, spatial learning, memory, and on insulin-like growth factor-1 (IGF-1), which is known to play a role in early brain development in rats. Spatial learning and memory were impaired by exposure to 0.3% CO2 air, while exposure to 0.1 and 0.3% CO2 air elevated blood corticosterone levels, intensified anxiety behavior, increased superoxide dismutase (SOD) enzyme activity and MDA levels in hippocampus and PFC; glutathione peroxidase (GPx) enzyme activity decreased in the PFC with no associated change in the hippocampus. IGF-1 levels were decreased in the blood, PFC and hippocampus by exposure to both 0.1 and 0.3% CO2. In addition, apoptosis was increased, while cell numbers were decreased in the CA1 regions of hippocampus and PFC after 0.3% CO2 air exposure in adolescent rats. A positive correlation was found between the blood IGF-1 level and apoptosis in the PFC. We found that chronic exposure to 0.3% CO2 air decreased IGF-1 levels in the serum, hippocampus and PFC, and increased oxidative stress. These findings were associated with increased anxiety behavior, and impaired memory and learning. |
| Databáze: | OpenAIRE |
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