Influence of Methylenetetrahydrofolate Reductase ( MTHFR ) C677T Polymorphism, B Vitamins and Other Factors on Plasma Homocysteine and Risk of Thromboembolic Disease in Chinese
| Autor: | Chao-Hung Ho, Jyh-Pyng Gau, Yuan-Bin Yu, Chi-Woon Kong, Wing-Keung Chau, Hui-Chi Hsu, Benjamin Ing-Tiau Kuo |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Deep vein Coronary Disease folic acid level Gastroenterology Coronary artery disease Folic Acid Risk Factors Thromboembolism Diabetes mellitus Internal medicine medicine Humans Vitamin B12 Homocysteine Methylenetetrahydrofolate Reductase (NADPH2) methylenetetrahydrofolate reductase polymorphism Aged Medicine(all) Aged 80 and over thromboembolic disease Genetics lcsh:R5-920 Polymorphism Genetic medicine.diagnostic_test biology business.industry plasma homocysteine level vitamin B6 and B12 levels Complete blood count General Medicine Middle Aged medicine.disease Thrombosis Vitamin B 6 Vitamin B 12 B vitamins medicine.anatomical_structure Methylenetetrahydrofolate reductase Mutation biology.protein Female lcsh:Medicine (General) business |
| Zdroj: | Journal of the Chinese Medical Association, Vol 68, Iss 12, Pp 560-565 (2005) |
| ISSN: | 1726-4901 |
| Popis: | Background: Thromboembolic disease is a major cause of morbidity and mortality in many countries. Our previous study found that Chinese subjects carried the same polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene as described in Western studies. The aim of the present study was to determine the influence of MTHFR polymorphism, B vitamins and other factors on plasma homocysteine (Hcy) levels and risk of thromboembolic disease in Chinese. Methods: One hundred and six subjects were enrolled into the study. They were categorized into 4 groups: healthy individuals (n = 42); those with diabetes mellitus (n = 20); those with deep vein thrombosis (DVT) (n = 11); and those with coronary artery disease (CAD) (n = 33). Plasma levels of folic acid, vitamins B6 and B12, Hcy, and fasting blood sugar were measured; total cholesterol, triglycerides, complete blood count, and 677 C→T mutation in MTHFR were determined. Results: Plasma Hcy was lowest in the healthy subjects, higher in diabetics, followed by patients with DVT, and highest in patients with CAD (p < 0.001, ANOVA). MTHFR C677T polymorphism was the common factor affecting plasma logHcy levels in all 4 groups of subjects. Triglycerides affected plasma logHcy in the CAD patients. For the 4 groups as a whole, MTHFR polymorphism, triglycerides, and vitamin B12 were the most significant factors influencing plasma Hcy. Conclusion: We suggest that high plasma Hcy is an important risk factor for CAD. Other factors including MTHFR polymorphism, vitamin B12, triglycerides, total cholesterol, and gender might affect Hcy levels in different diseases and conditions. (J Chin Med Assoc 2005;68(12):560-565) |
| Databáze: | OpenAIRE |
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