A Mild and Highly Convenient Chemoselective Alkylation of Thiols Using Cs2CO3—TBAI

Autor:	Terrence Gavin, Ralph Nicholas Salvatore, Robert A. Smith, Adam K. Nischwitz
Rok vydání:	2006
Předmět:	inorganic chemicals chemistry.chemical_classification Aryl Organic Chemistry chemistry.chemical_element General Medicine Alkylation Tetrabutylammonium iodide Biochemistry Sulfur chemistry.chemical_compound chemistry Thioether Yield (chemistry) Drug Discovery Moiety Carbonate Organic chemistry Alkyl
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
Popis:	A mild and improved method for the synthesis of thioethers has been developed. In the presence of cesium carbonate, tetrabutylammonium iodide, and DMF, various alkyl and aryl thiols underwent S-alkylation to afford structurally diverse sulfides in high yield. Unprotected mercaptoalcohols and thioamines reacted chemoselectively at the sulfur moiety exclusively. An example of a one-pot, solid-phase synthesis of a thioether is also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80096851f4475b28cd96b06f8f0b7ab https://doi.org/10.1002/chin.200613101 Zobrazit plný text záznamu Plný text