Transcranial direct current stimulation combined with exercise modulates the inflammatory profile and hyperalgesic response in rats subjected to a neuropathic pain model: Long-term effects

Autor: Camila Lino de Oliveira, Gabriela Gregory Regner, Stefania Giotti Cioato, Helouise Richardt Medeiros, Felipe Fregni, Vanessa Silva de Souza, Iraci Lucena da Silva Torres, Wolnei Caumo, Liciane Fernandes Medeiros, Bettega Costa Lopes
Rok vydání: 2020
Předmět:
Male
medicine.medical_treatment
Exercício
Transcranial Direct Current Stimulation
Neuropathic pain
Bimodal tDCS
0302 clinical medicine
Dor
Transcranial direct-current stimulation
General Neuroscience
05 social sciences
Chronic pain
Brain
Citocinas
Combined Modality Therapy
Sciatic Nerve
Treatment Outcome
Nociception
medicine.anatomical_structure
Spinal Cord
Hyperalgesia
Anesthesia
Cytokines
Sciatic nerve
Inflammation Mediators
Analgesic
Biophysics
050105 experimental psychology
lcsh:RC321-571
03 medical and health sciences
Physical Conditioning
Animal
medicine
Animals
Aerobic exercise
0501 psychology and cognitive sciences
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
business.industry
Spinal cord
medicine.disease
Hiperalgesia
Rats
Estimulação transcraniana por corrente contínua
Inflamação
Neuralgia
Neurology (clinical)
business
030217 neurology & neurosurgery
Modelos animais
Zdroj: Brain Stimulation, Vol 13, Iss 3, Pp 774-782 (2020)
Repositório Institucional do Centro Universitário La Salle
Universidade La Salle (UNILASALLE)
instacron:UNILASALLE
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
ISSN: 1935-861X
DOI: 10.1016/j.brs.2020.02.025
Popis: Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-08-02T19:11:58Z No. of bitstreams: 1 bclopes.etal2.pdf: 928490 bytes, checksum: bf669722d86cf476c34fed69f52984f4 (MD5) Made available in DSpace on 2021-08-02T19:11:58Z (GMT). No. of bitstreams: 1 bclopes.etal2.pdf: 928490 bytes, checksum: bf669722d86cf476c34fed69f52984f4 (MD5) Previous issue date: 2020 Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-08-02T19:12:18Z No. of bitstreams: 1 bclopes.etal2.pdf: 928490 bytes, checksum: bf669722d86cf476c34fed69f52984f4 (MD5) Made available in DSpace on 2021-08-02T19:12:18Z (GMT). No. of bitstreams: 1 bclopes.etal2.pdf: 928490 bytes, checksum: bf669722d86cf476c34fed69f52984f4 (MD5) Previous issue date: 2020 Background Behavioral alterations, like mechanical and thermal hyperalgesia, and modulation of biomarkers in the peripheral and central nervous systems (CNS) are markers of chronic pain. Transcranial direct current stimulation (tDCS) with exercise is a promising therapy for pain due to its neuromodulatory capacity. Objective To assess the individual effects of tDCS, exercise, and the two combined on the nociceptive response and BDNF, IL-1β, and IL-4 levels in the CNS structures of rats in a chronic pain model. Methods For 8 consecutive days after the establishment of chronic neuropathic pain by inducing a constriction injury to the sciatic nerve (CCI), the rats received tDCS, exercise, or both treatments combined (20 min/day). The hyperalgesic response was assessed by von Frey and hot plate tests at baseline, 7, and 14 days after CCI surgery and immediately, 24 h, and 7 days after the end of treatment. The BDNF, IL-1β, and IL-4 levels were assessed in the cerebral cortex, brainstem, and spinal cord by enzyme-linked immunosorbent assay at 48 h and 7 days after the end of treatment. Results The CCI model triggered marked mechanical and thermal hyperalgesia. However, bimodal tDCS, aerobic exercise, and the two combined relieved nociceptive behavior for up to 7 days following treatment completion. Conclusions Bimodal tDCS, aerobic exercise, or both treatments combined promoted analgesic effects for neuropathic pain. Such effects were reflected by cytokine modulation throughout the spinal cord-brainstem-cerebral cortex axis.
Databáze: OpenAIRE
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