Neuroimmune-Driven Neuropathic Pain Establishment: A Focus on Gender Differences
| Autor: | Francesca Guida, Mariantonietta Scafuro, Livio Luongo, Serena Boccella, Vincenzo Coraggio, Domenico Romano, Sabatino Maione, Salvatore Paino |
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| Přispěvatelé: | Coraggio, V., Guida, F., Boccella, S., Scafuro, M., Paino, S., Romano, D., Maione, S., Luongo, L. |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Neuroimmunomodulation T cell microglia Review Catalysis Proinflammatory cytokine lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences Sex Factors 0302 clinical medicine Immune system T-cell T-Lymphocyte Subsets medicine Animals Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy allodynia neuropathic pain Microglia business.industry Organic Chemistry General Medicine medicine.disease Computer Science Applications 030104 developmental biology medicine.anatomical_structure Allodynia lcsh:Biology (General) lcsh:QD1-999 Hyperalgesia Immune System Neuropathic pain Neuralgia Female medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 19, Iss 1, p 281 (2018) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms19010281 |
| Popis: | The role of neuroinflammatory cells in the establishment of neuropathic pain has been investigated in depth in the last few years. In particular, microglia have been shown to be key players in the induction of tactile allodynia, as they release proinflammatory molecules that, in turn, sensitize nociceptive neurons within the spinal cord. However, the role of peripheral immune cells such as macrophages, infiltrating monocytes, mast cells, and T-cells has been highlighted in the last few studies, even though the data are still conflicting and need to be clarified. Intriguingly, the central (microglia) and peripheral (T-cell)-adaptive immune cells that orchestrate maladaptive process-driven neuropathic pain seem to be involved in a gender-dependent manner. In this review, we highlight the role of the microglia and peripheral immune cells in chronic degenerative disease associated with neuro-immune-inflammatory processes. |
| Databáze: | OpenAIRE |
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