Liposomal Bupivacaine as a Single-Injection Peripheral Nerve Block
| Autor: | Timothy Furnish, Nisha Malhotra, Michael C. Donohue, Brian M. Ilfeld, Sarah J. Madison |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Drug Time Factors media_common.quotation_subject medicine.medical_treatment Clinical Sciences Pharmacology Peripheral nerve block Cohort Studies Dose-Response Relationship Clinical Research Anesthesiology Peripheral Nervous System Humans Medicine Anesthetics Local Anesthetics media_common Bupivacaine Drug Carriers Dose-Response Relationship Drug business.industry Neurosciences Evaluation of treatments and therapeutic interventions Nerve Block Single injection Liposomal Bupivacaine Treatment Outcome Anesthesiology and Pain Medicine medicine.anatomical_structure Local 6.1 Pharmaceuticals Delayed-Action Preparations Peripheral nervous system Anesthesia Liposomes Nerve block Female Drug carrier business medicine.drug |
| Zdroj: | Ilfeld, BM; Malhotra, N; Furnish, TJ; Donohue, MC; & Madison, SJ. (2013). Liposomal bupivacaine as a single-injection peripheral nerve block: A dose-response study. Anesthesia and Analgesia, 117(5), 1248-1256. doi: 10.1213/ANE.0b013e31829cc6ae. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/39g4d6r3 Anesthesia and analgesia, vol 117, iss 5 |
| ISSN: | 0003-2999 |
| DOI: | 10.1213/ane.0b013e31829cc6ae |
| Popis: | BACKGROUND: Currently available local anesthetics approved for single-injection peripheral nerve blocks have a maximum duration of 40 mg, tolerance to cutaneous current did not return to within 20% above baseline until after 24 hours in 100% of subjects (95% CI, 56%-100%). MVIC did not consistently return to within 20% of baseline until after 24 hours in 90% of subjects (95% CI, 54%-100%). Motor block duration was not correlated with bupivacaine dose (0.06 hour/mg, SE = 0.14, 95% CI, ?0.27 to 0.39, P = 0.707). CONCLUSIONS: The results of this investigation suggest that deposition of a liposomal bupivacaine formulation adjacent to the femoral nerve results in a partial sensory and motor block of >24 hours for the highest doses examined. However, the high variability of block magnitude among subjects and inverse relationship of dose and response magnitude attests to the need for a phase 3 study with a far larger sample size, and that these results should be viewed as suggestive, requiring confirmation in a future trial. Copyright © 2013 International Anesthesia Research Society. |
| Databáze: | OpenAIRE |
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