Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans
| Autor: | Nicolas Blanchard, Philippe Bisseret, Sarah Saint-Auret, Hajer Abdelkafi, Didier Le Nouen |
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| Přispěvatelé: | Laboratoire de chimie moléculaire (LCM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Substances naturelles/chimie moléculaire, Université Louis Pasteur - Strasbourg I-Ecole européenne de chimie, polymères et matériaux [Strasbourg]-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'innovation moléculaire et applications (LIMA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry 010402 general chemistry medicine.disease_cause biology.organism_classification 01 natural sciences 0104 chemical sciences Microbiology Hydroboration chemistry.chemical_compound Mycobacterium ulcerans medicine BSM Mycolactone Exotoxin |
| Zdroj: | Organic Chemistry Frontiers Organic Chemistry Frontiers, Royal Society of Chemistry, 2017, 4, pp.2380-2386. ⟨10.1039/C7QO00608J⟩ |
| ISSN: | 2052-4129 |
| DOI: | 10.1039/C7QO00608J⟩ |
| Popis: | Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans, has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a particularly challenging hydroboration reaction of a functionalized and sterically demanding 1,1-disubstituted exo-alkene. The full account of these investigations is discussed. |
| Databáze: | OpenAIRE |
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