Entacapone-induced hepatotoxicity and hepatic dysfunction
| Autor: | Alexander A. Fisher, James Croft-Baker, Patrick M Purcell, Michael Davis, Allan J. McLean |
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| Rok vydání: | 2002 |
| Předmět: |
Drug
media_common.quotation_subject Catechols Disease Pharmacology Antiparkinson Agents Liver Function Tests Nitriles medicine Humans Entacapone Drug Interactions Adverse effect media_common Aged business.industry Catechol O-Methyltransferase Inhibitors Parkinson Disease Discontinuation Neurology Drug Therapy Combination Female Neurology (clinical) Chemical and Drug Induced Liver Injury Hepatic dysfunction business medicine.drug |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 17(6) |
| ISSN: | 0885-3185 |
| Popis: | We describe 2 patients with Parkinson's disease who developed hepatotoxicity associated with the use of entacapone, a novel, mainly peripheral acting inhibitor of catechol-D-methyltransferase. Hepatotoxicity resolved rapidly with discontinuation of the drug. Analysis of causality in a further case initially linked to entacapone exposure was confounded by conflicting serial adverse reaction reports. |
| Databáze: | OpenAIRE |
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