Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions
| Autor: | D. C. Rao, Timothy S. Church, Kenneth R. Wilund, Jacob L. Barber, Kim M. Huffman, Mark A. Sarzynski, Rian Q. Landers-Ramos, Michael W. Beets, Conrad P. Earnest, Paul D. Thompson, Arthur S. Leon, James S. Skinner, David B. Bartlett, William E. Kraus, Richard L. Seip, Cris A. Slentz, Claude Bouchard, James M. Hagberg |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Magnetic Resonance Spectroscopy Time Factors Down-Regulation 030204 cardiovascular system & hematology Fibrinogen Systemic inflammation Article Young Adult 03 medical and health sciences 0302 clinical medicine Endurance training Regular exercise Internal medicine Inflammatory marker medicine Humans Exercise Aged Glycated Hemoglobin Exercise intervention business.industry Middle Aged Cardiometabolic disease Exercise Therapy 030104 developmental biology Physical Endurance Cardiology Biomarker (medicine) Female Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug |
| Zdroj: | Atherosclerosis. 277:1-6 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2018.07.029 |
| Popis: | Background and aims GlycA is a relatively new biomarker for inflammation as well as cardiometabolic disease risk. However, the effect of exercise on GlycA is largely unknown. Therefore, the purpose of this study was to examine the effects of regular exercise on the inflammatory marker GlycA across seven studies and 14 exercise interventions. Methods Nuclear magnetic resonance spectroscopy, specifically signal amplitudes originating from the N-acetyl methyl group protons of the N-acetylglucosamine residues on the glycan branches of glycoproteins, was used to quantify GlycA concentrations. GlycA was measured before and after completion of an exercise intervention in 1568 individuals across seven studies and 14 exercise interventions. Random effects inverse variance weighting models were used to pool effects across interventions. Results Combined analysis of unadjusted data showed that regular exercise significantly (p = 2 × 10−6) reduced plasma GlycA (−8.26 ± 1.8 μmol/L). This reduction remained significant (−9.12 ± 1.9 μmol/L, p = 1.22 × 10−6) following adjustment for age, sex, race, baseline BMI, and baseline GlycA. Changes in GlycA were correlated with changes in traditional inflammatory markers, C-reactive protein, interleukin-6, and fibrinogen, however, these correlations were relatively weak (range r: 0.21–0.38, p Conclusions Regular exercise significantly reduced plasma GlycA across 14 different exercise interventions despite differences in exercise programs and study populations. The current study provides a greater understanding of the use of exercise as a potential therapy for the reduction of systemic inflammation. Further research is needed to understand the mechanisms behind the exercise-related reductions in GlycA. |
| Databáze: | OpenAIRE |
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