Hepatoprotective effects of vitamin E against hexachlorobenzene-induced hepatotoxicity and oxidative stress in rats: histological, biochimical and antioxidant status changes
| Autor: | Laurence Payrastre, Hela Chalouati, Mohamed Moncef Ben Sâad |
|---|---|
| Přispěvatelé: | ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Université de Tunis El Manar (UTM), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty hepatotoxicity Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment [SDV]Life Sciences [q-bio] vitamin E 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Antioxidants Superoxide dismutase Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Liver Function Tests Internal medicine medicine Hexachlorobenzene Animals oxidative stress HCB Rats Wistar 0105 earth and related environmental sciences Liver injury chemistry.chemical_classification 0303 health sciences biology Dose-Response Relationship Drug Chemistry Glutathione peroxidase Vitamin E 030302 biochemistry & molecular biology lipid peroxidation Glutathione medicine.disease 3. Good health Disease Models Animal Endocrinology Liver biology.protein Chemical and Drug Induced Liver Injury Oxidative stress Biomarkers |
| Zdroj: | Toxicology Mechanisms and Methods Toxicology Mechanisms and Methods, Taylor & Francis, 2019, 29 (1), pp.18-25. ⟨10.1080/15376516.2018.1506847⟩ |
| ISSN: | 1537-6516 1537-6524 |
| DOI: | 10.1080/15376516.2018.1506847⟩ |
| Popis: | International audience; The protective effects of alpha-Tocopherol (vitamin E) on liver injury induced by hexachlorobenzene (HCB) were investigated in adult male rats of Wistar strain. Animals were randomly divided into six groups of eight rats each. Group 1 and 2 have received HCB, dissolved in olive oil, at a dose of 4 mg or 16 mg/kg b.w., respectively. Group 3 and 4 were treated by the same doses of HCB (4 mg and 16 mg/kg b.w.) after 1 h of pretreatment with alpha-tocopherol at a dose of 100 mg kg(-1) b.w. The other two groups served as controls; which received either olive oil only, a solvent of HCB, or alpha-tocopherol. A significant increase in hepatic lipid peroxidation (LPO) and GSH activity were observed following HCB administration. The activities of antioxidant enzymes like superoxide dismutase and catalase were significantly decreased while glutathione peroxidase was significantly increased following HCB administration. Similarly, a significant increase in plasma levels of various marker enzymes [aminotransferase (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)] and a decrease of total protein level were observed. Pretreatment with vitamin E of HCB treated rats ameliorated all biochemical parameters to near normal values. Liver histological study confirmed biochemical parameters and the beneficial role of vitamin E. |
| Databáze: | OpenAIRE |
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