Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse
| Autor: | Noriyasu Ota, Nishimura Hitomi, Masaki Yamamoto, Kensuke Misawa, Ishida Keiko, Koichi Misawa, Akira Shimotoyodome |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Male Amyloid Amyloid β Quinic Acid Spatial Learning Morris water navigation task Hippocampus Mice Transgenic Plaque Amyloid Pharmacology Coffee 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Chlorogenic acid Alzheimer Disease Memory Morris Water Maze Test Medicine Animals Cognitive Dysfunction Novel object recognition Cerebral Cortex Amyloid beta-Peptides business.industry General Neuroscience Brain Polyphenols Cognition General Medicine Disease Models Animal 030104 developmental biology chemistry Polyphenol Chlorogenic Acid business Open Field Test 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience research. 154 |
| ISSN: | 1872-8111 |
| Popis: | Epidemiological studies have found that habitual coffee consumption may reduce the risk of Alzheimer's disease. Coffee contains numerous phenolic compounds (coffee polyphenols) such as chlorogenic acids. However, evidence demonstrating the contribution of chlorogenic acids to the prevention of cognitive dysfunction induced by Alzheimer's disease is limited. The present study investigated the effect of chlorogenic acids on the prevention of cognitive dysfunction in APP/PS2 transgenic mouse model of Alzheimer's disease. Five-week-old APP/PS2 mice were administered a diet supplemented with coffee polyphenols daily for 5 months. The memory and cognitive function of mice was determined using the novel object recognition test, Morris water maze test, and the step-through passive avoidance test. Immunohistochemical analysis revealed that chronic treatment with coffee polyphenols prevented cognitive dysfunction and significantly reduced the amount of amyloid β (Aβ) plaques in the hippocampus. Furthermore, we determined that 5-caffeoylquinic acid, one of the primary coffee polyphenols, did not inhibit Aβ fibrillation; however, degraded Aβ fibrils. In conclusion, our results demonstrate that coffee polyphenols prevent cognitive deficits and reduce Aβ plaque deposition via disaggregation of Aβ in the APP/PS2 mouse. |
| Databáze: | OpenAIRE |
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