Oxidative Stress and Antioxidant Status in Patients with Bell’s Palsy
| Autor: | Münir Demirci, Engin Dursun, Metin Çeliker, Suat Terzi, Adnan Yilmaz, Abdulkadir Özgür, Zerrin Özergin Coşkun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
total antioxidant status Antioxidant medicine.medical_treatment Disease medicine.disease_cause Gastroenterology lcsh:Biochemistry Mononeuropathy 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine total oxidant status Bell's palsy Medicine oxidative stress lcsh:QD415-436 Risk factor 030223 otorhinolaryngology Original Paper Palsy business.industry Bell’s palsy medicine.disease business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of Medical Biochemistry Journal of Medical Biochemistry, Vol 36, Iss 1, Pp 18-22 (2017) |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | Bell's palsy (BP) is the most common acute mononeuropathy of unilateral facial paralysis. Immune, infective and ischaemic mechanisms are potential contributors to the development of BP, but the precise cause remains unclear. Recently, oxidative stress has been proposed as a risk factor of various idiopathic diseases. The aim of this study was to investigate the possible role of oxidative stress in patients with BP.Thirty-two patients with BP and 30 healthy controls were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were measured by the Erel method.Serum TOS activities and OSI values were significantly higher in patients with BP compared with the control group (P0.003 for all comparisons), whereas there was no significant difference between the groups in terms of TAS levels (P0.05).The data suggest that oxidative stress is increased in BP. These results of high oxidative stress in patients with BP may be helpful to clarify the etiopathogenesis of BP and contribute to improvement in the management or prevention of the disease.Belova paraliza (BP) najčešća je akutna mononeuropatija unilateralne facijalne paralize.Razvoju BP potencijalno doprinose imunski, infektivni i ishemijski mehanizmi, ali precizni uzrok ostaje nepoznat. Oksidativni stres nedavno je predložen kao faktor rizika za razna idiopatska oboljenja. Cilj ove studije bio je da se istraži potencijalna uloga oksidativnog stresa kod obolelih od BP.U ovu studiju uključeno je 32 obolelih od BP i 30 zdravih kontrolnih ispitanika. Ukupni oksidantni status (TOS) u serumu, ukupni antioksidantni status (TAS) i indeks oksidativnog stresa (OSI) mereni su Erelovom metodom.Aktivnosti TOS u serumu i vrednosti OSI bile su značajno povišene kod obolelih od BP u poređenju s kontrolnom grupom (P0,003 za sva poređenja), dok u pogledu nivoa TAS nisu uočene značajne razlike (P0,05) između grupa.Podaci pokazuju da je oksidativni stres povišen u BP. Dobijeni rezultati o povišenom oksidativnom stresu kod obolelih od BP mogu pomoći da se rasvetli etiopatogeneza BP i doprineti boljem menadžmentu ili prevenciji ove bolesti. |
| Databáze: | OpenAIRE |
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