Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease
| Autor: | Aline L. Dierschnabel, Luiz Eduardo Mateus Brandão, Regina H. Silva, José R. Santos, Clésio Andrade Lima, Charles dos Santos Estevam, Clarissa Loureiro das Chagas Campêlo, Murilo Marchioro, Alessandra Mussi Ribeiro, Rovena C.G.J. Engelberth, Diana Aline Nôga, Jeferson S. Cavalcante, Ramón H. Lima, Ywlliane da Silva Rodrigues Meurer |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Passiflora cincinnata Parkinson's disease Article Subject Tyrosine hydroxylase business.industry Pars compacta Dopaminergic Substantia nigra lcsh:Other systems of medicine Catalepsy Pharmacology Reserpine medicine.disease lcsh:RZ201-999 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Complementary and alternative medicine Anesthesia Medicine business 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017) Evidence-based Complementary and Alternative Medicine : eCAM |
| Popis: | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Pro-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN) Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN/MCT/CNPq/CT-INFRA Grant) Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25mg/kg, i.p.). Catalepsy, open field, oralmovements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD. Univ Fed Rio Grande do Norte, Natal, RN, Brazil Univ Fed Sergipe, Sao Cristovao, Brazil Univ Fed Sao Paulo, Sao Paulo, SP, Brazil Univ Fed Sao Paulo, Santos, SP, Brazil Univ Fed Sao Paulo, Sao Paulo, SP, Brazil Univ Fed Sao Paulo, Santos, SP, Brazil CNPq: 480115/2010-9 FAPERN/MCT/CNPq/CT-INFRA Grant: 013/2009 FAPESP: 2015/03354-3 Web of Science |
| Databáze: | OpenAIRE |
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