Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery
| Autor: | Young Hwan Kim, Bom Sahn Kim, Joon Young Choi, Sang Soo Cho |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Thalamus Amnesia Hippocampus Statistical parametric mapping Sensitivity and Specificity Nuclear Medicine and Molecular Imaging 03 medical and health sciences 0302 clinical medicine Amnesia Transient Global Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Cysteine Tomography Emission-Computed Single-Photon business.industry Brain Retrograde amnesia Organotechnetium Compounds Middle Aged medicine.disease nervous system Cerebral blood flow Cerebrovascular Circulation 030220 oncology & carcinogenesis Transient global amnesia Female Radiopharmaceuticals medicine.symptom Cardiology and Cardiovascular Medicine business Nuclear medicine Perfusion 030217 neurology & neurosurgery |
| Zdroj: | Diagnostic and Interventional Radiology. 22:476-480 |
| ISSN: | 1305-3612 1305-3825 |
| DOI: | 10.5152/dir.2016.15487 |
| Popis: | Purpose Transient global amnesia (TGA) is characterized by sudden loss of memory of recent events, transient inability to retain new information, and retrograde amnesia. We investigated the changes of regional cerebral blood flow in patients with TGA shortly after symptom onset and after recovery using Tc-99m-ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m ECD SPECT) and statistical parametric mapping (SPM) analysis. Methods Six right-handed patients with TGA were studied using Tc-99m ECD SPECT shortly after symptom onset and after recovery. As a control group, six healthy individuals were also studied. Images were analyzed using SPM8 using voxel-based analysis to estimate the differences between TGA patients and controls. Results There was significant hypoperfusion in the left hippocampus, left thalamus, and bilateral cerebellum. In the follow-up SPECT scan, hypoperfusion in hippocampus and thalamus were restored, while hypoperfusion was noted in the temporoparietal region. Conclusion Our results suggest that the underlying mechanism of TGA may be temporary ischemia in the hippocampus and thalamus. There was significant restoration of perfusion in the hippocampus and thalamus after recovery from TGA. |
| Databáze: | OpenAIRE |
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