Effects of Xanthohumol-rich Extract from the Hop on Fatty Acid Metabolism in Rats Fed a High-fat Diet
| Autor: | Kyoichi Osada, Kazuki Yui, Ayane Kiyofuji |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Humulus lupulus General Chemical Engineering Flavonoid Gene Expression Diet High-Fat Weight Gain Hop (networking) Feces chemistry.chemical_compound Overnutrition medicine Animals Obesity RNA Messenger Food science Rats Wistar Humulus Triglycerides Fatty acid synthesis Flavonoids chemistry.chemical_classification Propiophenones biology Fatty acid metabolism Plant Extracts Fatty Acids food and beverages Organ Size General Medicine General Chemistry biology.organism_classification medicine.disease Dietary Fats Rats Intestinal Absorption Liver chemistry Biochemistry Xanthohumol Adiponectin Anti-Obesity Agents Sterol Regulatory Element Binding Protein 2 |
| Zdroj: | Journal of Oleo Science. 63:159-168 |
| ISSN: | 1347-3352 1345-8957 |
| DOI: | 10.5650/jos.ess13136 |
| Popis: | Xanthohumol is the major prenylated flavonoid of female inflorescences of the hop plant (Humulus lupulus L.) and is a hydrophobic flavonoid. We examined the effects of dietary xanthohumol-rich hop extract in obese rats that was induced by feeding a high-fat diet. Dietary xanthohumol-rich hop extract significantly lowered the body weight gain of these rats compared to rats fed a high-fat diet without the extract. The increase of body weight, liver weight, and triacylglycerol levels in the plasma and liver of the rats fed a high-fat diet was ameliorated by dietary xanthohumol-rich hop extract. Dietary xanthohumol-rich hop extract tended to reduce hepatic fatty acid synthesis through the reduction of hepatic SREBP1c mRNA expression in the rats fed a high-fat diet. The excreted of triacylglycerol into feces also was promoted by dietary xanthohumol-rich hop extract. Plasma adiponectin levels in the rats fed a high-fat diet also tended to be elevated by dietary xanthohumol-rich hop extract. Thus, xanthohumol-rich hop extract may inhibit the increase of body weight, liver weight, and triacylglycerol in the plasma and liver induced by feeding high-fat diet through the regulation of hepatic fatty acid metabolism and inhibition of intestinal fat absorption. Therefore, xanthohumol-rich hop extract may exert preventive function on the increase of body weight and tissue triacylglycerol levels by overnutrition. |
| Databáze: | OpenAIRE |
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