Role of sphingosine-1-phosphate mediated signalling in systemic lupus erythematosus
| Autor: | He Ji, Yanhong Wang, Jia Yang, Taiping Huang, Jing Kang, Yun Zhou, Weiping Fan, Juanjuan Wang, Sijia Chang, Jihua Tian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Autoimmune disease Systemic lupus erythematosus Physiology business.industry Kinase Multiple sclerosis Sphingosine kinase Cell Biology medicine.disease Biochemistry Pathogenesis chemistry.chemical_compound Immune system chemistry immune system diseases Sphingosine Immunology Medicine lipids (amino acids peptides and proteins) Sphingosine-1-phosphate Lysophospholipids skin and connective tissue diseases business |
| Zdroj: | Prostaglandinsother lipid mediators. 156 |
| ISSN: | 1098-8823 |
| Popis: | Systemic lupus erythematosus (SLE) is a highly prevalent autoimmune disease characterized by the malfunction of the immune system and the persistent presence of an inflammatory environment. Multiple organs can be affected during SLE, leading to heterogeneous manifestations, which eventually result in the death of patients. Due to the lack of understanding regarding the pathogenesis of SLE, the currently available treatments remain suboptimal. Sphingosine-1-phosphate (S1P) is a central bioactive lipid of sphingolipid metabolism, which serves a pivotal role in regulating numerous physiological and pathological processes. As a well-recognized regulator of lymphocyte trafficking, S1P has been shown to be closely associated with autoimmune diseases, including SLE. Importantly, S1P levels have been found to be elevated in patients with SLE. In murine models of lupus, the increased levels of S1P also contribute to disease activity and organ impairment. Moreover, data from several studies also support the hypothesis that S1P receptors and its producer-sphingosine kinases (SPHK) may serve as the potential targets for the treatment of SLE and its co-morbidities. Given the significant success that intervening with S1P signaling has achieved in treating multiple sclerosis, further exploration of its role in SLE is necessary. Therefore, the aim of the present review is to summarize the recent advances in understanding the potential mechanism by which S1P influences SLE, with a primary focus on its role in immune regulation and inflammatory responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect