Bdellovibrio bacteriovorus : a potential ‘living antibiotic’ to control bacterial pathogens
| Autor: | Jan Maarten van Dijl, Alexander W. Friedrich, Lorea Jordana, Corinna Glasner, Francis M Cavallo |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Bacterial Infections/microbiology Gram-Positive Bacteria/physiology medicine.drug_class 030106 microbiology Antibiotics Drug Resistance Bdellovibrio bacteriovorus/growth & development Biology Applied Microbiology and Biotechnology Microbiology 03 medical and health sciences Antibiotic resistance Antibiosis medicine Animals Biofilms/growth & development Probiotics Bacterial General Medicine biology.organism_classification Bdellovibrio bacteriovorus 030104 developmental biology Biological Control Agents behavior and behavior mechanisms Gram-Negative Bacteria/drug effects Microbial Interactions Bacteria |
| Zdroj: | Critical Reviews in Microbiology |
| ISSN: | 1549-7828 1040-841X |
| DOI: | 10.1080/1040841x.2021.1908956 |
| Popis: | Bdellovibrio bacteriovorus is a small Deltaproteobacterium which, since its discovery, has distinguished itself for the unique ability to prey on other Gram-negative bacteria. The studies on this particular "predatory bacterium", have gained momentum in response to the rising problem of antibiotic resistance, because it could be applied as a potential probiotic and antibiotic agent. Hereby, we present recent advances in the study of B. bacteriovorus, comprehending fundamental aspects of its biology, obligatory intracellular life cycle, predation resistance, and potential applications. Furthermore, we discuss studies that pave the road towards the use of B. bacteriovorus as a "living antibiotic" in human therapy, focussing on its interaction with biofilms, the host immune response, predation susceptibility and in vivo application models. The available data imply that it will be possible to upgrade this predator bacterium from a predominantly academic interest to an instrument that could confront antibiotic resistant infections. |
| Databáze: | OpenAIRE |
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