Blood Stream Infections from MDR Bacteria
Autor: | Vincenzo Pota, Aniello Alfieri, Ciro Fittipaldi, Maria Beatrice Passavanti, Sveva Di Franco, Maria Caterina Pace, Pasquale Sansone, Marco Fiore |
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Přispěvatelé: | Di Franco, Sveva, Alfieri, Aniello, Pace, Maria Caterina, Sansone, Pasquale, Pota, Vincenzo, Fittipaldi, Ciro, Fiore, Marco, Passavanti, Maria Beatrice |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty bloodstream infections Science 030106 microbiology multidrug-resistant pathogen bloodstream infection Review intensive care unit General Biochemistry Genetics and Molecular Biology law.invention Sepsis 03 medical and health sciences 0302 clinical medicine Antibiotic resistance law Intensive care Epidemiology medicine Global health 030212 general & internal medicine Intensive care medicine Ecology Evolution Behavior and Systematics biology business.industry Septic shock Paleontology medicine.disease biology.organism_classification Intensive care unit Acinetobacter baumannii multidrug-resistant pathogens Space and Planetary Science septic shock business |
Zdroj: | Life, Vol 11, Iss 575, p 575 (2021) Life |
ISSN: | 2075-1729 |
Popis: | Background: Bloodstream infections (BSIs) constitute a growing public health concern, are among the most severe nosocomial pathologies, and are considered a worldwide cause of unfaithful outcomes, increasing treatment costs and diagnostic uncertainties. BSIs are one of the most frequent lethal conditions that are managed in intensive care units (ICUs). In the case of septic shock, immune deficiency, and delayed treatment, even with adequate antimicrobial therapy and/or source control, the outcomes are often unfavorable. Methods: this review article summarizes the epidemiological and microbiological characteristics of BSIs with a particular focus on ICU acquired BSIs (ICU-BSIs), which are usually caused by multidrug-resistant (MDR) pathogens. For this reason, their antimicrobial resistance patterns and therapeutic options have also been compiled. Results: ICU-acquired BSIs prevail in 5–7% of ICU patients. Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosae are the pathogens most often responsible for MDR infections. MDR Enterobacteriaceae have seen their prevalence increase from 6.2% (1997–2000) to 15.8% (2013–2016) in recent years. Conclusions: Considering that prevention and treatment of sepsis is nowadays considered a global health priority by the World Health Organization, it is our obligation to invest more resources into solving or reducing the spread of these unfaithful infections. It is relevant to identify patients with risk factors that make them more susceptible to BSIs, to guarantee earlier molecular or microbiological diagnoses, and more rapidly appropriate treatment by using de-escalation strategies where possible. |
Databáze: | OpenAIRE |
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