Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder
| Autor: | Jordi Ortiz-Gil, Benedikt L. Amann, Joaquim Radua, Peter J. McKenna, R. Salvador, Paloma Fernández-Corcuera, Jesus J. Gomar, Noemi Moro, Caterina del Mar Bonnín, Eduard Vieta, Ramon Landin-Romero, Erick J. Canales-Rodríguez, Silvia Alonso-Lana, Edith Pomarol-Clotet, Mercè Madre, Salvador Sarró, J. Blanch, Ana Moreno-Alcázar, Gemma C. Monté, Jose Manuel Goikolea |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Schizoaffective disorder Bipolar disorder Neuroimaging Brain mapping Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Humans voxel‐based morphometry Schizo-phrenia Gray Matter Psychiatry schizo‐phrenia bipolar disorder Brain Mapping neuroimaging Case-control study Brain Voxel-based morphometry Original Articles Middle Aged medicine.disease schizoaffective disorder 030227 psychiatry Psychiatry and Mental health Diffusion Magnetic Resonance Imaging Psychotic Disorders Schizophrenia Case-Control Studies Original Article Female Abnormality Psychology 030217 neurology & neurosurgery |
| Zdroj: | Acta Psychiatrica Scandinavica Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| ISSN: | 1600-0447 0001-690X |
| Popis: | Amann BL, Canales-Rodriguez EJ, Madre M, Radua J, Monte G,Alonso-Lana S, Landin-Romero R, Moreno-Alcazar A,Bonnin CM, Sarro S, Ortiz-Gil J, Gomar JJ, Moro N,Fernandez-Corcuera P, Goikolea JM, Blanch J, Salvador R, Vieta E,McKenna PJ, Pomarol-Clotet E. Brain structural changes inschizoaffective disorder compared to schizophrenia and bipolar disorder.Objective: Brain structural changes in schizoaffective disorder, and howfar they resemble those seen in schizophrenia and bipolar disorder, haveonly been studied to a limited extent.Method: Forty-five patients meeting DSM-IV and RDC criteria forschizoaffective disorder, groups of patients with 45 matchedschizophrenia and bipolar disorder, and 45 matched healthy controlswere examined using voxel-based morphometry (VBM).Results: Analyses comparing each patient group with the healthycontrol subjects found that the patients with schizoaffective disorderand the patients with schizophrenia showed widespread andoverlapping areas of significant volume reduction, but the patients withbipolar disorder did not. A subsequent analysis compared the combinedgroup of patients with the controls followed by extraction of clusters. Inregions where the patients differed significantly from the controls, nosignificant differences in mean volume between patients withschizoaffective disorder and patients with schizophrenia in any of fiveregions of volume reduction were found, but mean volumes in thepatients with bipolar disorder were significantly smaller in three of five.Conclusion: The findings provide evidence that, in terms of structuralgray matter brain abnormality, schizoaffective disorder resemblesschizophrenia more than bipolar disorder. |
| Databáze: | OpenAIRE |
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