Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood – the Cardiovascular Risk in Young Finns Study
| Autor: | Nina Hutri-Kähönen, Merja Kallio, Terho Lehtimäki, Markus Juonala, Jarkko S. Heiskanen, Jorma Viikari, Jussi Hernesniemi, Eero Jokinen, Mika Kähönen, Tomi Laitinen, Olli T. Raitakari, Päivi Tossavainen, Saku Ruohonen, Jaakko Nevalainen |
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| Přispěvatelé: | HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital, Tampere University, Clinical Medicine, TAYS Heart Centre, Department of Paediatrics, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Chemistry, Health Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatric Obesity Adolescent Heart Ventricles body mass index 030204 cardiovascular system & hematology 3121 Internal medicine left ventricular mass Left ventricular mass 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Humans 030212 general & internal medicine Risk factor Child Finland 2. Zero hunger Ventricular Remodeling business.industry nutritional and metabolic diseases blood pressure General Medicine Middle Aged Early life 3. Good health medicine.anatomical_structure Blood pressure risk factor Ventricle Heart Disease Risk Factors 3121 General medicine internal medicine and other clinical medicine Cardiology Original Article epidemiology Female Hypertrophy Left Ventricular business Body mass index Research Article |
| Zdroj: | Annals of Medicine article-version (VoR) Version of Record |
| ISSN: | 1365-2060 0785-3890 |
| Popis: | Background Increased left ventricular mass (LVM) predicts cardiovascular events and mortality. The objective of this study was to determine whether early-life exposures to body mass index (BMI) and systolic blood pressure (SPB) affects the left ventricular structure in adulthood. Methods We used longitudinal data from a 31-year follow-up to examine the associations between early-life (between ages 6-18) BMI and SPB on LVM in an adult population (N = 1864, aged 34-49). The burden of early-life BMI and SBP was defined as area under the curve. Results After accounting for contemporary adult determinants of LVM, early-life BMI burden associated significantly with LVM (3.61 g/SD increase in early-life BMI; [1.94 - 5.28], p 25 kg/m(2)) associated with 4.7% (2.5-6.9%, p 30kg/m(2)) resulted in a 21% (17.3-32.9%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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