Fluctuations in GAD65 Antibodies After Clinical Diagnosis of IDDM in Young Children
| Autor: | M Pina, Henk-Jan Aanstoot, P Mulder, M R Batstra, G.J. Bruining, J Quan, C. de Beaufort |
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| Přispěvatelé: | Pediatrics, Epidemiology |
| Rok vydání: | 1997 |
| Předmět: |
endocrine system
Time Factors endocrine system diseases Endocrinology Diabetes and Metabolism Glutamate decarboxylase chemistry.chemical_compound Insulin Infusion Systems Glutamate Dehydrogenase Diabetes mellitus Internal Medicine Humans Medicine Longitudinal Studies Child Autoantibodies Advanced and Specialized Nursing C-Peptide biology business.industry C-peptide Autoantibody Infant medicine.disease Titer Diabetes Mellitus Type 1 chemistry El Niño Child Preschool Immunology biology.protein Hemoglobin Antibody business Biomarkers Follow-Up Studies |
| Zdroj: | Diabetes Care, 20(4), 642-644. American Diabetes Association Inc. |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.20.4.642 |
| Popis: | OBJECTIVE To investigate whether the presence of GAD antibodies at onset of IDDM correlates to a more aggressive rate of β-cell destruction after clinical onset. RESEARCH DESIGN AND METHODS We studied GAD antibodies at onset of disease, after 1 year, and after 6 years in 33 consecutively referred children (mean age 8.08, range 1.7–16.3). In a subset of 11 patients, GAD antibodies were studied very frequently. The correlation between GAD antibodies and clinical parameters, including glycosylated hemoglobin, residual insulin secretion, and insulin dosage, was evaluated. RESULTS GAD antibody titers were highly variable. Four patients became GAD antibody positive weeks to years after clinical onset. Other patients switched between testing positive and negative for GAD antibodies shortly after clinical onset. No correlation was found between the presence of GAD antibodies and the rate of β-cell destruction, but patients with high GAD antibody indexes at onset had significantly higher glycosylated hemoglobin levels. CONCLUSIONS GAD antibodies at clinical onset do not predict the rate of β-cell destruction in young children with newly diagnosed IDDM. The highly variable GAD antibody levels suggest variation of the autoimmune process. |
| Databáze: | OpenAIRE |
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