Clinical Efficacy of Citalopram Alone or Augmented with Bupropion in Methadone-Stabilized Patients
| Autor: | Rhonda Pruzinsky, Alison Oliveto, Kishorchandra Gonsai, Gerardo Gonzalez, Mehmet Sofuoglu, Thomas R. Kosten, James Poling |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Population Medicine (miscellaneous) Citalopram Placebo behavioral disciplines and activities Cocaine-Related Disorders Dopamine Uptake Inhibitors Double-Blind Method mental disorders medicine Humans Clinical efficacy education Bupropion Depressive Disorder education.field_of_study business.industry Middle Aged Opioid-Related Disorders Anxiety Disorders Analgesics Opioid Clinical trial Psychiatry and Mental health Clinical Psychology Anesthesia Drug Therapy Combination Female Opiate business Methadone Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | American Journal on Addictions. 16:187-194 |
| ISSN: | 1521-0391 1055-0496 |
| Popis: | Despite the success of opiate-agonist therapies such as methadone for the treatment of opiate addiction, treatment response is not complete. This study evaluates the efficacy of citalopram augmented with bupropion in the treatment of illicit opiate use in a methadone-stabilized population. We conducted a 12-week randomized, double-blind, outpatient clinical trial in which 60 subjects were randomized into one of three treatment groups: placebo, citalopram (40 mg/day) plus placebo, or citalopram (40 mg/day) plus bupropion (50 mg/day). The results indicate that neither citalopram nor citalopram augmented with bupropion were more effective than placebo in the treatment of opioid abuse. |
| Databáze: | OpenAIRE |
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