Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants: The Hokkaido study on environment and children's health
| Autor: | Shizue Kato, Kaori Fujikura, Sachiko Itoh, Machiko Minatoya, Chihiro Miyashita, Yoichi Chisaki, Keiko Yamazaki, Tamiko Ikeno, Atsuko Araki, Reiko Kishi, Futoshi Mizutani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Thyroid Hormones
Mothers Physiology 010501 environmental sciences 01 natural sciences Biochemistry 03 medical and health sciences Dieldrin chemistry.chemical_compound 0302 clinical medicine Japan Thyroid-stimulating hormone Pregnancy Hydrocarbons Chlorinated Humans Medicine 030212 general & internal medicine Pesticides Child Adverse effect 0105 earth and related environmental sciences General Environmental Science business.industry Thyroid Child Health Infant Organochlorine pesticide Thyroid hormone medicine.anatomical_structure chemistry Maternal Exposure Prenatal Exposure Delayed Effects Organochlorine pesticides Gestation Population study Female Pregnancy exposure business Birth cohort Hormone |
| Zdroj: | Environmental Research. 189:109840 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/j.envres.2020.109840 |
| Popis: | Organochlorine pesticides (OCPs) are environmental contaminants with potentially adverse effects on neurodevelopment. Previous findings on the association between prenatal exposure to OCPs and the maternal or infant thyroid hormone system are inconsistent. Moreover, the influence of exposure to multiple OCPs and other chemical compounds is not clearly understood. Our study therefore aimed to examine the association between OCP exposure and both maternal and infant thyroid hormone systems. We also explored multiple exposure effects of OCPs and the influence of each compound using weighted quantile sum (WQS) methods. The study population included 514 participants in the Hokkaido study, recruited from 2002 to 2005 at one hospital in Sapporo, Japan. To quantify 29 OCPs, maternal blood samples were analyzed using gas chromatography/mass spectrometry. Blood samples for measuring thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from mothers during the early gestational stage (mean 11.4 weeks), and from infants between 7 and 43 days of age. The data of 333 mother child pairs with OCP and thyroid hormone measurements were included in the final analyses. Multivariate regression models showed a negative association between maternal FT4 and levels of o,p’-dichlorodiphenyldichloroethylene (DDE), o,p’-dichlorodiphenyltrichloroethane (DDT), and dieldrin. The WQS analysis showed that o,p’-DDT (48.6%), cis-heptachlorepoxide (22.8%), dieldrin (15.4%) were the primary contributors to the significant multiple exposure effect of OCPs on maternal FT4. For infants, we found a positive association between FT4 and cis-nonachlor and mirex. The most contributory compounds in the multiple exposure effect were trans-nonachlor (27.1%) and cis-nonachlor (13.8%), while several compounds contributed to the WQS via small weights (0.4-9.1%). These results indicate that OCPs, even at very low levels, may influence maternal and child thyroid hormone levels, which could modulate child development. |
| Databáze: | OpenAIRE |
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