A comparison of the effects of low- and high-dose atorvastatin on lipoprotein metabolism and inflammatory cytokines in type 2 diabetes: Results from the Protection Against Nephropathy in Diabetes with Atorvastatin (PANDA) randomized trial

Autor: Safwaan Adam, Paul N. Durrington, See Kwok, J. Martin Gibson, Tarza Siahmansur, Handrean Soran, Martin K. Rutter, Jan H. Ho, Naveed Younis, Matthew Gittins, Jonathan Schofield, Yifen Liu
Rok vydání: 2017
Předmět:
Male
Very low-density lipoprotein
Endocrinology
Diabetes and Metabolism
Atorvastatin
Type 2 diabetes
030204 cardiovascular system & hematology
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Very-low-density lipoprotein
Glycated apolipoprotein B
Nutrition and Dietetics
Anticholesteremic Agents
Low-density lipoprotein
Middle Aged
Inflammatory cytokines
Lipoproteins
LDL
Treatment Outcome
Cytokines
lipids (amino acids
peptides
and proteins)
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Apolipoprotein B
medicine.drug
medicine.medical_specialty
Down-Regulation
030209 endocrinology & metabolism
Drug Administration Schedule
Nephropathy
03 medical and health sciences
Double-Blind Method
Internal medicine
Diabetes mellitus
Type 2 diabetes mellitus
Internal Medicine
medicine
Therapeutic targets
Albuminuria
Humans
Triglycerides
Aged
Apolipoproteins B
Serum Amyloid A Protein
Dose-Response Relationship
Drug
business.industry
nutritional and metabolic diseases
Cholesterol
LDL
medicine.disease
Endocrinology
chemistry
Diabetes Mellitus
Type 2
business
Zdroj: Soran, H, Liu, Y, Adam, S, Siahmansur, T, Ho, J H, Schofield, J D, Kwok, S, Gittins, M, France, M, Younis, N, Gibson, J M, Durrington, P N & Rutter, M K 2017, ' A comparison of the effects of low-and high-dose atorvastatin on lipoprotein metabolism and inflammatory cytokines in type 2 diabetes : Results from the Protection Against Nephropathy in Diabetes with Atorvastatin (PANDA) randomized trial ', Journal of Clinical Lipidology . https://doi.org/10.1016/j.jacl.2017.10.011
ISSN: 1933-2874
DOI: 10.1016/j.jacl.2017.10.011
Popis: Background: Statin therapy is recommended in type 2 diabetes (T2DM) although views on treatment intensity and therapeutic targets remain divided. Objectives: Our objectives were to compare the effects of high-intensity and moderate-intensity atorvastatin treatment on lipoprotein metabolism and inflammatory markers and how frequently treatment goals are met in high-risk T2DM patients. Methods: Patients with T2DM and albuminuria (urinary albumin:creatinine ratio >5 mg/mmol, total cholesterol
Databáze: OpenAIRE
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