Toxicologic studies of fenfluramine
| Autor: | Geoffrey Woodard, John W. Ward, Bernard V. Franko, K.D. Courtney, Donald L. Gilbert |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
Bradycardia Opisthotonus medicine.medical_specialty Fenfluramine media_common.quotation_subject Guinea Pigs Toxicology Lethal Dose 50 Mice Dogs Sex Factors Pregnancy Internal medicine medicine Mydriasis Animals Weaning media_common Pharmacology business.industry Reproduction Ovary Prostate Appetite Haplorhini Organ Size Rats Endocrinology Cats Gestation Female Rabbits medicine.symptom business Weight gain medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 19:705-711 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(71)90302-4 |
| Popis: | An account of toxicologic studies of fenfluramine HCl (N-ethyl-α-methyl-3-trifluoromethylphenethylamine hydrochloride), an appetite suppressant, is presented. Mice, rats, guinea pigs, rabbits, monkeys, dogs, and cats, and the iv, ip and po (capsule and diet) routes of administration were involved in acute, subchronic, chronic, reproduction, and teratologic studies. Effects noted in acute studies were tremors, clonic convulsions, rigidity of the limbs, opisthotonus, mydriasis, lacrimation, chromodacryorrhea, salivation, vocalization, cutaneous hyperemia, piloerection, and hyperresponsiveness to tactile stimuli. Animals in subchronic and chronic studies were less active and showed slight bradycardia (dogs) and a slight to moderate reduction in food consumption and weight gain. Results were essentially negative with regard to clinical studies, gross findings at autopsy, changes in organ to body weight ratios, and histopathology. Most deaths were apparently due to respiratory failure. Teratologic information was negative. Reproduction studies showed decreases in rate of conception and in survival weight at weaning among animals at higher dose levels of fenfluramine. Weight gain was reduced during gestation in treated females. |
| Databáze: | OpenAIRE |
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