Aflatoxins in food products consumed in Brazil: a preliminary dietary risk assessment

Autor:	M. Homem de Mello, Eloisa Dutra Caldas, Patrícia Diniz Andrade, J.A. França
Rok vydání:	2013
Předmět:	Aflatoxin medicine.medical_specialty Health Toxicology and Mutagenesis Food Contamination Toxicology Body weight Risk Assessment chemistry.chemical_compound food Aflatoxins Environmental health Humans Medicine Food science Mycotoxin Exposure assessment business.industry Public health Public Health Environmental and Occupational Health Environmental Exposure General Chemistry General Medicine food.food chemistry business Risk assessment Brazil Food Analysis Food Science Brazil nut Food contaminant
Zdroj:	Food Additives & Contaminants: Part A. 30:127-136
ISSN:	1944-0057 1944-0049
Popis:	A preliminary dietary exposure assessment for aflatoxins (AFs; AFB1, AFB2, AFG1 and AFG2) was conducted to evaluate the potential carcinogenic risks for the Brazilian population. AF concentration data in food were obtained from analysis reports issued by the Central Public Health Laboratory of the Federal District (LACEN-DF) and from published work. Food consumption and body weight (bw) data were obtained from a national survey conducted in 2008/2009. Cancer risks arising from exposure to aflatoxins were assessed using the carcinogenic potency of AFs estimated by the JECFA, and hepatitis B virus prevalence in the Brazilian population. Additionally, margins of exposure (MOE) were also calculated for the various scenarios investigated. A total of 942 food samples were analysed for AFs in the Federal District between 2002 and 2011 with 4.5% of them being positive for at least one aflatoxin (LOQ = 2 µg kg(-1)). The highest percentage of contamination was found in peanuts (8.1%) and Brazil nuts (6.0%), with mean levels ranging from 6.7 µg kg(-1) in peanut products to 36.9 µg kg(-1) in Brazil nuts. Most of the studies conducted elsewhere in Brazil found similar results. Total AF intake for the total Brazilian population and high consumers of food relevant for AF contamination in Brazil (upper bound; samplesLOQ = 0.5 LOQ) were 6.8 and 27.6 ng kg(-1) bw day(-1), respectively. Cancer risk reached 0.0753 cancers year(-1) per 10(5) individuals for the total population and 0.3056 cancers year(-1) per 10(5) individuals for high consumers. MOE reached 25 and 6 for the total population and high consumers, respectively, indicating a potential risk for consumers. Aflatoxins are genotoxic carcinogens, and government action should be maintained and continuously improved in order to guarantee that human exposure levels are kept as low as possible.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a724a4ac46aa010a6826abb747822134 https://doi.org/10.1080/19440049.2012.720037 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.