Comparison of cerebrospinal fluid biomarkers between idiopathic normal pressure hydrocephalus and subarachnoid hemorrhage-induced chronic hydrocephalus: a pilot study
| Autor: | Yong Gu Chung, Chang In Lee, Jeong Hyun Lee, Dong Hyuk Park, Shin Hyuk Kang, Dong Bin Back, Jea Young Lee, Kyung Jae Park, Tai Hyoung Cho |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A congenital hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty normal pressure hydrocephalus Subarachnoid hemorrhage subarachnoid hemorrhage Enzyme-Linked Immunosorbent Assay Pilot Projects tau Proteins Preliminary Report cerebrospinal fluid Transforming Growth Factor beta1 total tau Cerebrospinal fluid Normal pressure hydrocephalus medicine Humans cardiovascular diseases Communicating hydrocephalus transforming growth factor-β1 Aged Aged 80 and over vascular endothelial growth factor business.industry Tumor Necrosis Factor-alpha General Medicine Middle Aged medicine.disease Chronic hydrocephalus Pathophysiology Hydrocephalus Normal Pressure Hydrocephalus nervous system diseases Case-Control Studies (Idiopathic) normal pressure hydrocephalus Chronic Disease Female tumor necrosis factor-α business Biomarkers |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| Popis: | Summary Background We examined the cerebrospinal fluid (CSF) markers of subarachnoid hemorrhage (SAH)-induced and idiopathic normal pressure hydrocephalus (INPH) to investigate the pathophysiology and mechanism of communicating hydrocephalus compared to obstructive hydrocephalus. Material/Methods We obtained CSF samples from 8 INPH, 10 SAH-induced hydrocephalus, and 6 unmatched patients with non-hemorrhagic obstructive hydrocephalus during their ventriculoperitoneal shunt operations. Transforming growth factor (TGF)-β1, tumor necrosis factor (TNF)-α, vascular endothelial growth factor (VEGF), and total tau in the CSF were analyzed via enzyme-linked immunosorbent assay. Results The mean VEGF levels in the CSF of patients with SAH-induced hydrocephalus, INPH, and obstructive hydrocephalus were 239±131, 239±75, and 163±122 pg/mL, respectively. The total tau concentrations in the CSF of the groups were 1139±1900, 325±325, and 1550±2886 pg/mL, respectively. TNF-α values were 114±34, 134±38, and 55±16 pg/mL, respectively. TGF-β1 values were 953±430, 869±447, and 136±63 pg/mL, respectively. A significant difference in TNF-α and TGF-β1 levels was observed only between SAH-induced and chronic obstructive hydrocephalus, and between INPH and chronic obstructive hydrocephalus (p |
| Databáze: | OpenAIRE |
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