Lobar Collapse and Obliteration of Air Bronchogram Allowing Early Diagnosis of Endobronchial Aspergillus Infection following Hematopoietic Stem Cell Transplantation
| Autor: | Manigandan Thyagarajan, Mary Morgan, Sarah J. Groves, David F. Weeden, Elizabeth L. Thompson, Colin G. Steward, Elizabeth M. Johnson |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty Aspergillus medicine.diagnostic_test biology business.industry medicine.medical_treatment lcsh:R895-920 Case Report General Medicine Hematopoietic stem cell transplantation Neutropenia biology.organism_classification medicine.disease Surgery Collapsed Lung Transplantation Bronchoscopy Respiratory failure medicine Stem cell business |
| Zdroj: | Case Reports in Radiology, Vol 2014 (2014) Case Reports in Radiology |
| ISSN: | 2090-6870 2090-6862 |
| Popis: | Endobronchial fungal infection (EBFI) is notoriously difficult to diagnose early since it may present few systemic features and does not cause characteristic parenchymal lesions on lung CT scanning. We report a 9-year-old girl who suffered extended neutropenia following graft failure after haematopoietic stem cell transplantation (HSCT) for severe aplastic anaemia. CT scan prior to retransplantation was normal despite persistent cough but lobar collapse was shown on repeat scan 16 days later. The probable diagnosis of EBFI (later proven on bronchoscopy) was only suspected when subsequent chest X-ray (CXR) demonstrated lack of an air bronchogram in the partially collapsed lung. Early radiological suspicion resulted in multiagent antifungal therapy followed by delayed lobectomy, and led to this being the first reported case ofAspergillusEBFI not to result in respiratory failure. |
| Databáze: | OpenAIRE |
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