The association of hs-CRP and fibrinogen with anthropometric and lipid parameters in non-obese adolescent girls with polycystic ovary syndrome
| Autor: | Petar D Simić, Svetlana Perovic, George Mastorakos, Djuro Macut, Tatjana Simic, Marija Pljesa-Ercegovac, Ilijana Mažibrada, Dragana Bojanin, Ljiljana Plavsic, Ana Savic-Radojevic, Jelica Bjekic-Macut, Tatjana Djukic |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Waist Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Fibrinogen Body Mass Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine medicine Humans 2. Zero hunger Anthropometry medicine.diagnostic_test biology Cholesterol business.industry C-reactive protein Lipids Polycystic ovary C-Reactive Protein chemistry Pediatrics Perinatology and Child Health biology.protein Female Insulin Resistance Waist Circumference Lipid profile business Body mass index Polycystic Ovary Syndrome medicine.drug Lipoprotein |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. |
| ISSN: | 2191-0251 0334-018X |
| Popis: | BackgroundThe aim of the study was to evaluate high-sensitivity C-reactive protein (hs-CRP) and fibrinogen in non-obese normoinsulinemic adolescent girls with polycystic ovary syndrome (PCOS) and their relationship with anthropometric and lipid parameters.MethodsThe study comprised a total of 26 adolescent girls newly diagnosed with PCOS and 12 healthy controls with regular ovulatory menstrual cycles. The concentration of hs-CRP, fibrinogen, anthropometric measurements, and biochemical and hormonal testing were assessed.ResultsPCOS adolescent girls had significantly higher levels of hs-CRP and fibrinogen compared to healthy controls. In univariate regression analysis, statistically significant associations of hs-CRP and fibrinogen levels of PCOS patients have been shown with body mass index (BMI), waist circumference (WC), hip circumference (HC) and low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio, while hs-CRP levels were also associated with cholesterol and LDL. In the multivariate regression model, we found that hs-CRP levels were predicted by BMI (β=0.541, pConclusionsWe have shown an association of proinflammatory indices hs-CRP and fibrinogen with anthropometric and lipid parameters of adolescent women with PCOS. The inflammatory markers might be useful in monitoring normal-weight adolescent women with PCOS in an effort to timely prevent unfavorable changes in body mass and lipid profile. |
| Databáze: | OpenAIRE |
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