Efficacy and Tolerance of Intravitreal Ganciclovir in Cytomegalovirus Retinitis in Acquired Immune Deficiency Syndrome
| Autor: | Lydie Zazoun, Shahin Gharakhanian, Sophie Matheron, Marie Lautier-Frau, Didier Ingrand, Christine Katlama, Patricia Marcel, Willy Rozenbaum, Isabelle Cochereau-Massin, Phuc LeHoang, Martin Robinet, Marc Gentilini |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Ganciclovir medicine.medical_specialty Congenital cytomegalovirus infection Eye Infections Viral Retinitis Endophthalmitis Maintenance therapy medicine Humans Prospective Studies Acquired Immunodeficiency Syndrome business.industry Retinal Detachment Drug Tolerance Retinite Middle Aged Eye infection medicine.disease Vitreous Hemorrhage Surgery Vitreous Body Ophthalmology Cytomegalovirus Infections Female Cytomegalovirus retinitis business Follow-Up Studies medicine.drug |
| Zdroj: | Ophthalmology. 98:1348-1355 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/s0161-6420(91)32135-3 |
| Popis: | Forty-four patients with acquired immune deficiency syndrome with cytomegalovirus (CMV) retinitis (64 eyes) intolerant of or refusing systemic antiviral therapy received 710 intravitreal injections of ganciclovir at the dosage of 400 Ag per injection. The patients were followed for -a mean period of 9 weeks. Induction therapy consisted of two injections a week until healing. Maintenance therapy consisted of one injection a week until relapse. All but 1 of 53 induction courses led to cicatrization, after a mean of 6.6 injections. In 54 maintenance courses, the 8-week relapse rate was 53%. During intravitreal therapy, involvement of the fellow eye occurred in 11% of the patients and CMV infection developed in a nonocular site in 16% of the patients. Five retinal detachments and two intravitreal hemorrhages occurred. No endophthalmitis or cataract was noted. Intravitreal ganciclovir appears to be a safe and effective alternative in patients intolerant of intravenous anti-CMV drugs. |
| Databáze: | OpenAIRE |
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