Efficacy and safety of a novel skin cleansing formulation versus chlorhexidine gluconate
| Autor: | Robert E. Boykin, Daryl S. Paulson, Robert Topp, Gregory S. Schultz, Qingping Yang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Silver Epidemiology medicine.drug_class Skin cleansing 030106 microbiology Dentistry INGUINAL REGIONS Surface-Active Agents 03 medical and health sciences 0302 clinical medicine Antiseptic Chlorhexidine gluconate medicine Humans 030212 general & internal medicine Skin business.industry Health Policy Chlorhexidine Public Health Environmental and Occupational Health Colloidal silver Confidence interval Infectious Diseases Anti-Infective Agents Local Female Dermatologic Agents business |
| Zdroj: | American Journal of Infection Control. 46:1262-1265 |
| ISSN: | 0196-6553 |
| DOI: | 10.1016/j.ajic.2018.04.232 |
| Popis: | Background This study evaluated whether a multi-ingredient surfactant colloidal silver technology was noninferior to a 4% chlorhexidine gluconate (CHG) antiseptic on immediate and persistent antimicrobial activity. Methods The inguinal regions of 81 healthy adults were demarcated into 4 quadrants, and 3 were used for testing each product at baseline, 10 minutes, and 6 hours postapplication. The log of the number of colony forming units was obtained using a cylinder sampling technique. The 95% confidence interval of the test product to the control product with a margin of 0.65 was established as the upper limit of noninferiority. Results A total of 81 individuals were enrolled. The colloidal silver product was found to be noninferior to 4% CHG at both 10 minutes and 6 hours postapplication. Conclusions The colloidal silver-based product was noninferior to the 4% CHG product at 10 minutes and 6 hours postapplication. |
| Databáze: | OpenAIRE |
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