Sleep disorders and the hypothalamus
| Autor: | Overeem, Sebastiaan, van Litsenburg, Raphaële R.L., Reading, Paul J., Swaab, Dick F., Buijs, Ruud M., Kreier, Felix |
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| Přispěvatelé: | Signal Processing Systems |
| Rok vydání: | 2021 |
| Předmět: |
Insomnia
Cataplexy Lateral hypothalamus Prader–Willi syndrome SDG 3 – Goede gezondheid en welzijn SDG 3 - Good Health and Well-being ROHHAD medicine Humans Tuberomamillary nucleus Sleep Wake Disorders/etiology Narcolepsy Hypersomnia Sleep disorder Narcolepsy/diagnosis Kleine–Levin syndrome Hypothalamus/metabolism business.industry Intracellular Signaling Peptides and Proteins Encephalitis lethargica Alzheimer's disease medicine.disease Neuropeptides/metabolism Orexin Hypersomnolence REM sleep medicine.symptom business Neuroscience |
| Zdroj: | The Human Hypothalamus: Neuropsychiatric Disorders ISBN: 9780128199732 The Human Hypothalamus: Neuropsychiatric Disorders, 369-385 STARTPAGE=369;ENDPAGE=385;TITLE=The Human Hypothalamus: Neuropsychiatric Disorders |
| DOI: | 10.1016/b978-0-12-819973-2.00025-3 |
| Popis: | As early as the 1920s, pathological studies of encephalitis lethargica allowed Von Economo to correctly identify hypothalamic damage as crucial for the profound associated sleep-related symptoms that helped define the condition. Only over the last 3 decades, however, has the key role of the hypothalamus in sleep-wake regulation become increasingly recognized. As a consequence, a close relation between abnormal sleep symptomatology and hypothalamic pathology is now widely accepted for a variety of medical disorders. Narcolepsy is discussed in some detail as the cardinal primary sleep disorder that is caused directly and specifically by hypothalamic pathology, most notably destruction of hypocretin (orexin)-containing neurons. Thereafter, various conditions are described that most likely result from hypothalamic damage, in part at least, producing a clinical picture resembling (symptomatic) narcolepsy. Kleine-Levin syndrome is a rare primary sleep disorder with intermittent symptoms, highly suggestive of hypothalamic involvement but probably reflecting a wider pathophysiology. ROHHAD (rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation) and Prader-Willi syndrome are also covered as hypothalamic syndromes with prominent sleep-related symptoms. Finally, sleep issues in several endocrine disorders are briefly discussed. |
| Databáze: | OpenAIRE |
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