Can blood serum amyloid A concentrations in horses differentiate synovial sepsis from extrasynovial inflammation and determine response to treatment?
| Autor: | Claire S Robinson, Luis M. Rubio-Martínez, Nicolas F. Villarino, Matthew Sinovich, Ellen R. Singer |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences Inflammation Gastroenterology 0403 veterinary science Sepsis sepsis Blood serum Internal medicine Synovial Fluid Medicine Synovial fluid Animals Serum amyloid A Horses Original Research Serum Amyloid A Protein General Veterinary business.industry Significant difference 0402 animal and dairy science Horse 04 agricultural and veterinary sciences General Medicine medicine.disease Prognosis 040201 dairy & animal science Response to treatment SAA horse Horse Diseases medicine.symptom business serum Biomarkers |
| Zdroj: | The Veterinary Record |
| Popis: | BackgroundSerum amyloid A (SAA) concentrations in blood and synovial fluid of horses with synovial sepsis have diagnostic value. Studies suggest serial blood SAA measurements could act as a prognostic indicator. This study evaluated the use of serial blood SAA concentrations for monitoring of horses with synovial sepsis.MethodsA prospective clinical trial was performed of horses referred to a single hospital with synovial sepsis that survived (n=17), synovial sepsis that were euthanised (n=5), non-septic intrasynovial pathologies (n=14) or extensive extrasynovial lacerations (n=5). SAA concentrations were determined on admission and every 24 hours thereafter. The area under the concentration–time curve from 0 to 144 hours of each group was compared by Kruskal-Wallis and post hoc Dunn’s tests (PResultsSignificant difference in mean blood concentration of SAA was found between synovial sepsis that survived and non-septic pathologies in the first 48 hours, as well as between non-septic intrasynovial pathologies and non-responsive sepsis requiring euthanasia. No difference was found between extensive extrasynovial lacerations and any septic group.ConclusionsWhile serial blood SAA is useful for monitoring clinical response of intrasynovial septic pathologies, interpretation should consider other clinical findings since blood SAA is not a specific marker for synovial sepsis. |
| Databáze: | OpenAIRE |
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