Chemoenzymatic Dynamic Kinetic Resolution of Amines in Fully Continuous-Flow Mode
| Autor: | Cristian Andrei Gal, Márk Oláh, János Kóti, László Poppe, János Éles, Gábor Hornyánszky, Csaba Paizs, József Nagy, Emese Farkas, Attila Földi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_element
010402 general chemistry 01 natural sciences Biochemistry Kinetic resolution Catalysis chemistry.chemical_compound Ammonium formate Organic chemistry Physical and Theoretical Chemistry Amines Racemization biology Molecular Structure 010405 organic chemistry Chemistry organic chemicals Organic Chemistry biology.organism_classification 0104 chemical sciences Kinetics Biocatalysis Thermodynamics Candida antarctica Isopropyl Palladium |
| Zdroj: | Organic letters. 20(24) |
| ISSN: | 1523-7052 |
| Popis: | In this study, lipase-mediated dynamic kinetic resolution (DKR) of various benzylic amines (1a–g) is presented which is realized in a so far unprecedented fully continuous-flow system. The DKR process applying sol–gel immobilized lipase B from Candida antarctica as biocatalyst, palladium on 3-aminopropyl-functionalized silica as racemization catalyst, isopropyl 2-ethoxyacetate as acylating agent, ammonium formate as hydrogen and nitrogen sources, and 2-methyl-2-butanol as solvent under regulated pressure provided the desired products in moderate to good yields with excellent enantiomeric excesses. |
| Databáze: | OpenAIRE |
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