Tendon Injury Produces Changes in SSCT and Nerve Physiology Similar to Carpal Tunnel Syndrome in an in Vivo Rabbit Model

Autor:	James D. Schmelzer, Peter C. Amadio, Phillip A. Low, Chunfeng Zhao, Kai Nan An, Stephen S. Cha, Tamami Moriya
Rok vydání:	2011
Předmět:	Surgery Articles medicine.medical_specialty Pathology business.industry Connective tissue medicine.disease Median nerve Tendon Plastic surgery medicine.anatomical_structure Fibrosis Orthopedic surgery medicine Orthopedics and Sports Medicine Surgery Carpal tunnel Carpal tunnel syndrome business
Zdroj:	HAND. 6:399-407
ISSN:	1558-9455 1558-9447
DOI:	10.1007/s11552-011-9356-2
Popis:	Background The etiology of carpal tunnel syndrome (CTS) remains idiopathic in many cases. Noninflammatory fibrosis of the subsynovial connective tissue (SSCT) within the carpal tunnel is common in CTS, and some clinicians have hypothesized that this fibrosis might be a cause rather than an effect of CTS. An animal model in which to test this hypothesis would be useful. The principal objective of this study was to investigate the effect of a surgical injury on SSCT fibrosis and median nerve function within the carpal tunnel in an in vivo rabbit model. Methods Rabbits were sacrificed 12 weeks after surgery and were evaluated by mechanical testing, histology, transmission and scanning electron microscopy, and electrophysiology. Results SSCT fibroblast density ( pConclusions Our findings are similar to those seen in patients with carpal tunnel syndrome and suggest that the tendon injury procedure may be the basis of a new animal model of SSCT injury and, possibly, CTS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bb226447e3c175192f4722451bc9c6 https://doi.org/10.1007/s11552-011-9356-2 Zobrazit plný text záznamu Full text from SpringerLink