Identification of deletion mutations and three new genes at the familial polyposis locus
| Autor: | E. Wolff, Jeff Stevens, John J. Wasmuth, Andrew Thliveris, Lisa Spirio, Janet A. Warrington, M. Carlson, Leslie Sargeant, Ray White, John Douglas Mcpherson, Hadi Abderrahim, Daniel Cohen, Lawrence Gelbert, Denis Le Paslier, Hans Albertsen, Mark Leppert, Geoff Joslyn, Karen Krapcho, Randall W. Burt, Joanna Groden, John P. Hughes, Wade S. Samowitz, Margaret Robertson |
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| Přispěvatelé: | Centre d'Etude du Polymorphisme Humain (CEPH), Fondation Jean Dausset-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7) |
| Rok vydání: | 1991 |
| Předmět: |
Candidate gene
Molecular Sequence Data Restriction Mapping [SDV.CAN]Life Sciences [q-bio]/Cancer Locus (genetics) Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Amino Acid Sequence Cloning Molecular Gene ComputingMilieux_MISCELLANEOUS 030304 developmental biology Genetics 0303 health sciences Signal recognition particle Base Sequence Nucleic acid sequence DNA Ribosomal RNA Molecular biology Pedigree chemistry Adenomatous Polyposis Coli 030220 oncology & carcinogenesis Deletion mutation Colonic Neoplasms Mutation Chromosome Deletion Polymorphism Restriction Fragment Length |
| Zdroj: | Cell Cell, Elsevier, 1991, 66 (3), pp.601-613. ⟨10.1016/0092-8674(81)90022-2⟩ |
| ISSN: | 0092-8674 1097-4172 |
| DOI: | 10.1016/0092-8674(81)90022-2⟩ |
| Popis: | Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19. |
| Databáze: | OpenAIRE |
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