Modulatory potential on immune system of a new alkaloid isolated from Coccinea cordifolia root
| Autor: | Jashabir Chakraborty, Saumendu Deb Roy, Suvakanta Dash, Ramesh Kumari Dasgupta |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Hemagglutination
Neutrophils 02 engineering and technology Plant Roots Biochemistry Mice 03 medical and health sciences Alkaloids Immune system Column chromatography Structural Biology Cell Adhesion medicine Animals Immunologic Factors Molecular Biology 030304 developmental biology 0303 health sciences Traditional medicine Chemistry Alkaloid General Medicine Levamisole Carbon-13 NMR 021001 nanoscience & nanotechnology Cucurbitaceae Titer Proton NMR 0210 nano-technology medicine.drug |
| Zdroj: | International Journal of Biological Macromolecules. 121:643-649 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2018.10.104 |
| Popis: | In this study, a new alkaloid was isolated from methanolic extract of Coccinea cordifolia root using flash chromatography and was subjected to spectral analysis like 1H NMR, 13C NMR, FTIR analysis and GCMS for confirming the structure of the isolated alkaloid. The isolated alkaloid was also subjected to immunomodulatory assays to verify its role in the claims against the plant. It was found that the isolated compound at a dose of 2.5 mg/kg has shown competitive immunomodulatory potential when evaluated by carbon clearance, delayed type hypersensitivity and haemagglutination titer models and using Levamisole at a dose of 50 mg/kg as the standard drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect