General Synthesis of 1-Aryl-6-azaisocytosines and Their Utilization for the Preparation of Related Condensed 1,2,4-Triazines
| Autor: | Jan Slouka, František Zálešák, Jakub Stýskala |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmaceutical Science
1-aryl-6-azaisocytosine 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Cytosine lcsh:Organic chemistry Drug Discovery Organic chemistry 1 2 4-triazine Physical and Theoretical Chemistry 030304 developmental biology Triazine cyclization of arylhydrazones 0303 health sciences Molecular Structure fused azaisocytosines 010405 organic chemistry Triazines Aryl Organic Chemistry Tautomer 0104 chemical sciences Pyrimidines chemistry Chemistry (miscellaneous) Cyclization Molecular Medicine condensed 1 2 4-triazine |
| Zdroj: | Molecules, Vol 24, Iss 19, p 3558 (2019) Molecules Volume 24 Issue 19 |
| ISSN: | 1420-3049 |
| Popis: | A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles 4 is described. This method is based on coupling diazonium salts with cyanoacetylcyanamide 2 and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides 3. The 6-azaisocytosines 4 were studied with respect to tautomeric equilibrium and the transformation of functional groups, and used in the synthesis of the condensed heterocyclic compounds: Purine isosteric imidazo[2,1-c]-[1,2,4]triazine 8 and the 1,2,4-triazino[2,3-a]quinazolines 9&ndash 12. |
| Databáze: | OpenAIRE |
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