Transient leukemia of Down syndrome

Autor: Sergiu P. Paşca, Mihnea Zdrenghea, Anca Colita, Delia Dima, Sorin Man, Gheorghe Popa, Cristina Stefan, Cristina Blag, Patric Teodorescu, Emil Puscas, Valentina Sas, Gabriela Zaharie, Seiji Kojima, Ciprian Tomuleasa, Bobe Petrushev, Sabina Iluta, Cosmin Lisencu, Mirela Marian, Nicolae Andronic-Gorcea, Ioana Berindan-Neagoe, Irina Camelia Chis
Rok vydání: 2019
Předmět:
Zdroj: Critical reviews in clinical laboratory sciences. 56(4)
ISSN: 1549-781X
Popis: Childhood leukemia is mostly a "developmental accident" during fetal hematopoiesis and may require multiple prenatal and postnatal "hits". The World Health Organization defines transient leukemia of Down syndrome (DS) as increased peripheral blood blasts in neonates with DS and classifies this type of leukemia as a separate entity. Although it was shown that DS predisposes children to myeloid leukemia, neither the nature of the predisposition nor the associated genetic lesions have been defined. Acute myeloid leukemia of DS is a unique disease characterized by a long pre-leukemic, myelodysplastic phase, unusual chromosomal findings and a high cure rate. In the present manuscript, we present a comprehensive review of the literature about clinical and biological findings of transient leukemia of DS (TL-DS) and link them with the genetic discoveries in the field. We address the manuscript to the pediatric generalist and especially to the next generation of pediatric hematologists.
Databáze: OpenAIRE
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