Dietary restriction improves fitness of ageing parents but reduces fitness of their offspring in nematodes
| Autor: | Martin I. Lind, Alexei A. Maklakov, Brian S. Mautz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0106 biological sciences Trade-offs THE JOURNAL OF GERONTOLOGY: Biological Sciences Aging Offspring media_common.quotation_subject Dietary restriction Longevity Fertility Evolution of ageing 010603 evolutionary biology 01 natural sciences Evolutionsbiologi AcademicSubjects/MED00280 03 medical and health sciences Temporary fasting Caloric Restriction and Dietary Interventions Lifespan extension Animals Body Size Sexual maturity Medicine Caloric Restriction 030304 developmental biology media_common 0303 health sciences Evolutionary Biology biology business.industry Reproduction Fasting Fecundity biology.organism_classification Transgenerational effects Caenorhabditis AcademicSubjects/SCI00960 Female Caenorhabditis remanei Geriatrics and Gerontology business Demography |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences The Journals of Gerontology: Series A |
| Popis: | Dietary restriction (DR) is a well-established intervention to extend lifespan across taxa. Recent studies suggest that DR-driven lifespan extension can be cost-free, calling into question a central tenant of the evolutionary theory of aging. Nevertheless, boosting parental longevity can reduce offspring fitness. Such intergenerational trade-offs are often ignored but can account for the “missing costs” of longevity. Here, we use the nematode Caenorhabditis remanei to test for effects of DR by fasting on fitness of females and their offspring. Females deprived of food for 6 days indeed had increased fecundity, survival, and stress resistance after re-exposure to food compared with their counterparts with constant food access. However, offspring of DR mothers had reduced early and lifetime fecundity, slower growth rate, and smaller body size at sexual maturity. These findings support the direct trade-off between investment in soma and gametes challenging the hypothesis that increased somatic maintenance and impaired reproduction can be decoupled. |
| Databáze: | OpenAIRE |
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