The emerging roles of circular RNAs in regulating the fate of stem cells
| Autor: | Lingfei Jia, Ziyao Zhuang, Yunfei Zheng, Weiran Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pluripotent Stem Cells Cellular differentiation Clinical Biochemistry Apoptosis Biology Autoimmune Diseases 03 medical and health sciences Mice 0302 clinical medicine Circular RNA Cell Line Tumor Neoplasms microRNA Animals Humans Cell Lineage Molecular Biology Cell Proliferation Medical treatment Cell growth Stem Cells Cell Differentiation Cell Biology General Medicine RNA Circular Cell biology MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Neoplastic Stem Cells Stem cell Biomarkers |
| Zdroj: | Molecular and cellular biochemistry. 476(1) |
| ISSN: | 1573-4919 |
| Popis: | Circular RNAs(circRNAs) are a large family of RNAs shaping covalently closed ring-like molecules and have become a hotspot with thousands of newly published studies. Stem cells are undifferentiated cells and have great potential in medical treatment due to their self-renewal ability and differentiation capacity. Abundant researches have unveiled that circRNAs have unique expression profile during the differentiation of stem cells and could serve as promising biomarkers of these cells. There are key circRNAs relevant to the differentiation, proliferation, and apoptosis of stem cells with certain mechanisms such as sponging miRNAs, interacting with proteins, and interfering mRNA translation. Moreover, several circRNAs have joined in the interplay between stem cells and lymphocytes. Our review will shed lights on the emerging roles of circRNAs in regulating the fate of diverse stem cells. |
| Databáze: | OpenAIRE |
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