Safety of in vitro amplified HLA-haploidentical donor immune cell infusions for childhood malignancies
| Autor: | Yan Chen, Xiaofei Sun, Yong Qiang Li, Rui Qing Cai, Jian Chuan Xia, Qi Jing Wang, Ke Pan, Jia Zhu, Fei Zhang, Fei Fei Sun, Jia He, Su Ying Lu, De Sheng Weng, Zi Jun Zhen, Juan Wang, Hai Xia Zheng |
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| Rok vydání: | 2013 |
| Předmět: |
Male
safety medicine.medical_specialty Epstein-Barr Virus Infections HLA-haploidentical donor cells medicine.medical_treatment Lymphoproliferative disorders Graft vs Host Disease Hematopoietic stem cell transplantation Childhood malignancies Gastroenterology Immunotherapy Adoptive Neuroblastoma Immune system Cytokine-Induced Killer Cells Internal medicine medicine Humans Transplantation Homologous Child Cytokine-induced killer cell business.industry Hematopoietic Stem Cell Transplantation Infant Immunotherapy medicine.disease Lymphoproliferative Disorders Killer Cells Natural Graft-versus-host disease Treatment Outcome Oncology Child Preschool Immunology Chills Female Original Article immunotherapy medicine.symptom business Progressive disease Follow-Up Studies |
| Zdroj: | Chinese Journal of Cancer |
| ISSN: | 1000-467X |
| Popis: | In vitro amplified human leukocyte antigen (HLA)-haploidentical donor immune cell infusion (HDICI) is not commonly used in children. Therefore, our study sought to evaluate its safety for treating childhood malignancies. Between September 2011 and September 2012, 12 patients with childhood malignancies underwent HDICI in Sun Yat-sen University Cancer Center. The median patient age was 5.1 years (range, 1.7-8.4 years). Of the 12 patients, 9 had high-risk neuroblastoma (NB) [7 showed complete response (CR), 1 showed partial response (PR), and 1 had progressive disease (PD) after multi-modal therapies], and 3 had Epstein-Barr virus (EBV)-positive lymphoproliferative disease (EBV-LPD). The 12 patients underwent a total of 92 HDICIs at a mean dose of 1.6×10(8) immune cells/kg body weight: 71 infusions with natural killer (NK) cells, 8 with cytokine-induced killer (CIK) cells, and 13 with cascade primed immune cells (CAPRIs); 83 infusions with immune cells from the mothers, whereas 9 with cells from the fathers. Twenty cases (21.7%) of fever, including 6 cases (6.5%) accompanied with chills and 1 (1.1%) with febrile convulsion, occurred during infusions and were alleviated after symptomatic treatments. Five cases (5.4%) of mild emotion changes were reported. No other adverse events occurred during and after the completion of HDIDIs. Neither acute nor chronic graft versus host disease (GVHD) was observed following HDICIs. After a median of 5.0 months (range, 1.0-11.5 months) of follow-up, the 2 NB patients with PR and PD developed PD during HDICIs. Of the other 7 NB patients in CR, 2 relapsed in the sixth month of HDICIs, and 5 maintained CR with disease-free survival (DFS) ranging from 4.5 to 11.5 months (median, 7.2 months). One EBV-LPD patient achieved PR, whereas 2 had stable disease (SD). Our results show that HDICI is a safe immunotherapy for childhood malignancies, thus warranting further studies. |
| Databáze: | OpenAIRE |
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