Efficacy of a new combination of fipronil and permethrin against Ctenocephalides felis flea infestation in dogs
| Autor: | Becky Fankhauser, Pascal Dumont, Bruce N. Kunkle, Theodore S. Chester, Soll Mark D, Lénaïg Halos, William R. Everett, James S. Hunter, Josephus J. Fourie |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Insecticides Veterinary medicine Efficacy Administration Topical Toxicology chemistry.chemical_compound Dogs Flea Infestations parasitic diseases Dog medicine Animals Dog Diseases Permethrin Fipronil Ctenocephalides Water exposure Shampoo biology Research Felis biology.organism_classification Ctenocephalides felis Infectious Diseases Flea infestation chemistry Drug Evaluation Pyrazoles Drug Therapy Combination Female Parasitology medicine.drug |
| Zdroj: | Parasites & Vectors |
| ISSN: | 1756-3305 |
| Popis: | Background Five studies were conducted to evaluate the effect of a new combination of fipronil and permethrin on cat fleas, Ctenocephalides felis, when applied to dogs, including dogs that underwent water exposure or shampooing. Methods In each study, 16 dogs were allocated to two groups. Each dog was infested with 100 unfed adult fleas on Days −1, 7, 14, 21 and 28. Eight dogs were treated with a new topical spot-on formulation containing 6.76% w/v fipronil + 50.48% w/v permethrinon Day 0; and eight dogs served as untreated controls. Twenty-four or 48 h after treatment or subsequent infestation, each dog was combed to remove and count live fleas. In addition, the dogs were subjected to different levels of water or shampoo exposure. In study 1, dogs were not subjected to any water exposure or shampooing; in study 2, dogs were water immersed twice during the month on Days 10 and 24; in study 3, dogs were water immersed three times on Days 10, 17 and 24; and in studies 4 and 5, dogs were shampooed once on Day 17. Results All groups of dogs administered a single topical treatment with a combination of fipronil and permethrin had significantly (p |
| Databáze: | OpenAIRE |
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